温江县钩端螺旋体病发病率大幅下降原因  

Study on Reasons of Leptospirosis Incidence Greatly Descending in Wenjiang County

作　　者：欧阳兵[1] 郭宗琪[1] 祝小平[1] 黄自英[1] 蔺鸿[1] 魏敏[1] 袁珩[1] 敖睿[1] 刘伦光[1] 张林[1] 刘骊生[1] 徐竹清[1] 庹晓金 孟丽 王志勇 杨红 钟明明 蒋丽 

机构地区：[1]四川省疾病预防控制中心,成都610031 [2]四川省温江县疾病预防控制中心

出　　处：《预防医学情报杂志》2005年第1期19-23,共5页Journal of Preventive Medicine Information

基　　金：卫生部课题 (编号WKJ -1999-0 1-0 1)

摘　　要：目的　研究温江县钩端螺旋体病发病率大幅下降原因 ,为防治提供科学依据。方法　传染源调查 ,人、动物血清抗体测定 ,分析与发病率关系。结果　田间啮齿目食虫目动物总带菌率、黑线姬鼠带菌率均与发病率呈正相关 (r =0 76 49、P <0 0 0 0 5 ;r=0 782 2、P <0 0 0 0 5 ) ;黑线姬鼠构成、带菌率由第 1位降为 0。自然人群抗体阳性率与发病率呈负相关 (r =- 0 16 39、P >0 0 5 ) ;自然人群抗体滴度、患者和动物中分离钩体 ,3者血清群以黄疸出血群最高 (GMT倒数平均值 =2 1 74、5 9 19%、 87 81% )。结论　黑线姬鼠是温江县钩体病主要传染源 ,其构成和田间啮齿目食虫目动物总带菌率皆降为 0 ,是该病发病率大幅下降主要原因。Objective To explore the reasons of leptospiosis rincidence greatly descending in Wenjiang county and to offer the evidence for preventing the leptospirosis scientifically. Method The source of infection was investigated, the blood antibody level in human and animals was detccted, and the relationship between the antibody level and the incidence was analyzed. Result Not only the total carrier rate of rodential and insectivorous field animals,but also the carrier rate of the apodemus agrarius had the positive correlation to the incidence(r=0.764 9,P<0.000 5;r=0.782 2, P<0.000 5),the quantity and carrier rate of the apodemus agrarius decreased from the first to zero. The antibody level in the healthy population presented negative correlation to its incidence. The antibody in the healthy population and the leptospirosis separated from patients and animals were mainly icterohaemorrhagiae serogroup(the reciprocal means of GMT were equal to 21.74%,59.19%,87.81%). Conclusion The reasons that leptospirosis incidence greatly descended are that the apodemus agrarius is the primary source of leptospirosis infection in WenJiang City and its quantity and the total carrier rate of rodential and insectivorous field animals decreased to zero.

关 键 词：自然疫源性疾病 钩端螺旋体病 传染源 

分 类 号：R514.4[医药卫生—内科学]