寿尔智胶囊对体外培养大鼠海马神经元细胞凋亡的影响  

EFFECT OF SHOU’ERZHI CAPSULE ON APOPTOSIS OF CULTUREDHIPPOCAMPUS NEURON CELL IN VTTRO

作　　者：冯方俊[1] 涂晋文[1] 董梦久[1] 陈克进[1] 熊家平[1] 

机构地区：[1]湖北中医学院附属医院,武汉430061

出　　处：《中国中医药科技》2005年第1期40-41,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的 :研究寿尔智胶囊对海马神经元细胞凋亡的影响 ,从而探讨中药防治阿尔茨海默病(Alzheimer’sdementia ,AD)的机理。方法 :运用血清药理学方法、流式细胞仪技术等 ,观察寿尔智胶囊含药血清对体外培养新生Wistar鼠海马神经元细胞凋亡的影响。结果 :寿尔智胶囊含药血清可以保护培养的海马神经元 ,具有抗凋亡作用。结论 :寿尔智胶囊有助于老年痴呆的防治 ,可发挥延缓衰老作用。Objective:The preventive and therapeutic mecanism of Alzheimer's dementia with traditional Chinese herbs has been studied by observing the effects of Shou'erzhi capsule upon the apoptosis of hippocampus neurons.Methods:Observing the influence of the serum with Shou'erzhi capsule upon the apoptosis of hippocampus neuron cultured in vitro of new-born Wistar rats by seropharmacology and cell-flow device.Results:Shou'erzhi capsule could protect cultured hippocampus neuron cell from apoptosis,there was obvious difference between Shou'erzhi group and other groups.Conclusion:Shou'erzhi capsule is helpful for the prevention of senile dementia,which can delay the process of senility.

关 键 词：寿尔智胶囊 体外培养 含药血清 大鼠海马 神经元细胞凋亡 影响 海马神经元细胞 结论 新生 目的 

分 类 号：R285[医药卫生—中药学]