伤寒菌苗免疫减轻兔动脉粥样硬化的机理  

THE MECHANISM OF ATHEROSCLEROTIC PLAQUES TO BE ATTEN UATED BY THE IMMUNIZATION WITH TYPHOID VACCINE

作　　者：姚君慎 段文卓[1] 刘同美[1] 崔希忠[1] 岳启安[2] 赵淑梅[2] 

机构地区：[1]潍坊医学院病理生理学教研室 [2]潍坊医学院微生物学教研室

出　　处：《潍坊医学院学报》1993年第2期81-84,共4页Acta Academiae Medicinae Weifang

摘　　要：为进一步明确伤寒菌苗免疫减轻兔动脉粥样硬化(动粥)的机理,将15只兔分为伤寒菌苗免疫组(n=8)和对照组(n=7),并测定免疫前后的血液流变学、血清脂质含量和细胞免疫功能的变化,结果血小板聚集活性由23.53±9.18降低到5.44±9.50,淋巴细胞增殖试验亦比对照组增强(P<0.05),细胞免疫功能免疫组为633.28±236.67cpm,对照组319.7±186.4cpm(P<0.05),但伤寒菌苗免疫对血液粘度和血清脂质代谢无明显影响,结果提示伤寒菌苗免疫与动粥病变呈明显相关性,同时可增强细胞免疫功能。Fifteen rabbits are used to divide to two groups in present investigation.Experimental group is an immunization with typhoid vaccine,control group is not immunized.Hemorheologic changes,the metabolism of lipids and cellular immunized function are determine in pre/post— immunization.This purpose is to indicate the mechanism of atherosclerostic lesions to be attenuat- ed by the immunization with typhoid vaccine.The results were demonstrated that the mechanism is possibly to lower aggregative rate of the platelet(23.53±9.18→5.44±9.50),because,the relation between aggregative rate of the platelet and athero—sclerotic lesions hase and apparent statistical significance;it is also probably due to strengthen the function of cell—mediated immu- nity(633.28±236.07;319.7±186.4cpm).The effect of the immunization with typhoid vac- cine on the visco—sity of whole blood and lipid's metabolism it not spparent.

关 键 词：动脉粥样硬化 免疫 伤寒菌苗 病理 

分 类 号：R543.502[医药卫生—心血管疾病]