BDT滤嘴对香烟烟雾凝聚物诱发微核率的降低作用  

The reductive effect of BDT fllter on the frequency of micronuclei induced by tobacco smoke condensate

作　　者：陈雯[1] 詹德进 陈家坤[1] 吴中亮[1] 杜应秀[1] 

机构地区：[1]广州医学院化学致癌研究所,510182

出　　处：《卫生毒理学杂志》1993年第3期170-172,共3页Journal of Health Toxicology

摘　　要：用双核微核法测定香烟烟雾凝聚物对BALB/c-3T3和CHL细胞的致微核作用。结果发现香烟烟雾凝聚物可使两种细胞的微核率升高,不需S_9的活化。比较不同滤嘴对香烟烟雾凝聚物中诱变物质的清除效果,发现普通滤嘴不能有效地降低微核率,而BDT滤嘴则能使微核率降低了一半左右。Tobacco smoke condensate incrased the frequency of micronuclei in BLAB/c-3T3. and CHLcells using cytokinesis-block (CB) method. This effect was observed without activaton by S9.The reductive effect on the frequency of micronuclei induced by tobacco smoke condensate wascompared between general and BDT filters. The results indicated that general filter can noteffectively reduce the frequency of micronuclei, but BDT filter can; and appoximately to onehalf.

关 键 词：双核微核法 香烟烟雾凝聚物 BDT滤嘴 卫生毒理 

分 类 号：R114[医药卫生—卫生毒理学]