补充抗氧化剂对力竭运动大鼠脑中自由基代谢的影响  

Antioxidant Supplement and Metabolism of Free Radicals in the Brain of Rats after Exhaustive Exercise

作　　者：解黎明[1] 李建春[1] 端礼荣[2] 周铁民[3] 赵德岭[3] 

机构地区：[1]江苏大学体育部,江苏镇江212013 [2]江苏大学医学院预防医学教研室,江苏镇江212001 [3]北京体育大学,北京100084

出　　处：《北京体育大学学报》2004年第12期1645-1646,共2页Journal of Beijing Sport University

摘　　要：为了探讨力竭性运动以及抗氧化剂营养干预对大鼠脑组织自由基代谢的影响,对抗氧化剂干预和运动对照组大鼠进行的游泳力竭游泳运动实验,测定各组大鼠大脑和小脑组织中的MDA、SOD及GSH-Px活性。结果表明:力竭组大鼠大脑中SOD、GSH-Px活性明显下降;小脑中GSH-Px活性下降;补充抗氧化剂组大鼠大脑SOD、GSH-Px活性显著高于力竭组;小脑中GSH-Px活性显著高于力竭组,其它指标无显著变化。结果提示,力竭性运动大鼠脑组织抗氧化酶活性有一定抑制作用,但MDA变化不明显;补充抗氧化剂可以提高脑组织的抗氧化酶的活性,对提高脑组织的抗氧化能力具有积极意义。To probe into the effect of exhaustive exercise and nutritional supplement on the metabolism of free radicals in the brain of rat. This experiment has research on the free radicals in rat's cerebrum and cerebellum after antioxidant supplement and exhaustive swimming exercise. The rats are randomly divided into two groups: exhaustive group and nutrition supplement goup. The result show that in the exhaustive group, the SOD, GSH-Px level in cerebrum and the GSH-Px level in cerebellum decreased while in the nutrition supplement group, the SOD, GSH-Px level in cerebrum and the GSH-Px level in cerebellum increased significantly. And we find no significant change of MDA. This result indicates that exhaustive exercise can decrease the antioxidase's activity in rat's brain and this decrease can be weakened through supplementing antioxidant.

关 键 词：抗氧化剂 力竭运动 脑组织 MDA、SOD活性 GSH—Px活性 

分 类 号：G804.32[文化科学—运动人体科学]