头孢哌酮舒巴坦对铜绿假单胞菌的抗菌活性  

Antibacterial activity of cefoperazone-sulbactam against pseudomonas aeruginase isolates

作　　者：周秀岚[1] 孙晓霞 闫静 王春泽 齐晓琴 赵建平[3] 

机构地区：[1]内蒙古医学院附属医院药局,呼和浩特010050 [2]呼和浩特市防疫站,监督所 [3]内蒙古自治区医院检验科

出　　处：《中国抗感染化疗杂志》2005年第1期44-45,共2页Chinese Journal of Infection and Chemotherapy

基　　金：内蒙古自治区科学技术攻关资助项目的内容(990122;20000211)。

摘　　要：目的通过127株铜绿假单胞菌对11种抗菌药物的比较,评价头孢哌酮-舒巴坦对铜绿假单胞菌的体外抗菌活性.方法细菌鉴定采用API系统和手工法,药敏试验采用K-B法,结果判定按NCCLS 2000年标准执行,数据统计采用上海金仕达软件.结果由铜绿假单胞菌引起的呼吸道感染最常见,其次为伤口感染和泌尿道感染.铜绿假单胞菌对头孢哌酮-舒巴坦敏感度最好(敏感率为91.0%),高于亚胺培南(71.7%);对头孢他啶、头孢哌酮、氨曲南的敏感率为67.7%～83.5%;对哌拉西林敏感率(72.6%)明显高于氨苄西林-舒巴坦和阿莫西林-克拉维酸(1.8%～7.1%)(P＜0.005).结论合理选择抗菌药物,及时有效地切断耐药菌株的传播,降低由铜绿假单胞菌引起的医院感染;头孢哌酮-舒巴坦在治疗由铜绿假单胞菌引起的感染中,具有较强的抗菌活性.Objective This study was designed to evaluate the in vitro activity of cefoperazone-sulbactam against 127 clinical isolates of Pseudomonas aeruginosa by comparing with other 12 comparators.MethodsAll isolates were identified with API system and conventional techniques.Kirby-Bauer disk method was used for susceptibility testing and the results were interpreted according to NCCLS breakpoints.Data were analyzed with Shanghai Kingstar Software.ResultsThe most common infection caused by P. aeruginosa was respiratory tract infection,followed by wound infection and urinary tract infection.Cefoperazone-sulbactam was the most active agent against P. aeruginosa (susceptibility rate of 91.0%),superior to imipenem(71.7%).About 67.7%-83.5% of the isolates tested were susceptible to ceftazidime,cefoperazone and aztreonam.Piperacillin was significantly more active than ampicillin-sulbactam and amoxicillin-clavulanic acid against P. aeruginosa isolates(with an inhibition rate of 72.6%.ConclusionRational selection of antibiotics timely and effectively interrupting the transmission of resistant P. aeruginosa are important for the reduction of hospital infections caused by P. aeruginosa Cefoperazone-sulbactam is comparatively more active against P. aeruginosa.

关 键 词：头孢哌酮-舒巴坦 铜绿假单胞菌 药敏试验 

分 类 号：R96[医药卫生—药理学]