血清前列腺特异性抗原浓度改变对慢性前列腺炎的临床意义  

Clinical Significance of Alterations in Serum Prostate Specific Antigen (PSA) in Chronic Prostatitis

作　　者：赵新求[1] 刘伟英[1] 陈宇东[1] 王领军[1] 李昱[1] 

机构地区：[1]解放军252医院泌尿外科,河北保定071000

出　　处：《华北国防医药》2005年第1期17-18,共2页Medical Journal of Beijing Military Region

摘　　要：目的:探讨慢性前列腺炎患者血清前列腺特异性抗原(PSA)浓度改变及其对本病诊断和治疗的作用。方法:选择20-60岁的 慢性前列腺炎患者360例,测定血清PSA浓度。根据前列腺按摩液(EPS)中的白细胞(WBC)记数的多少,将患者分为轻度炎症 (WBC<10/HP)、中度炎症(10/HP≤WBC<30/HP)、重度炎症(WBC≥30/HP)3组,并比较3组之间PSA水平的变化,其中180例 行。EPS细菌培养。结果:血清PSA升高比例为46.7％,其中轻度炎症组10％、中度炎症组10％、重度炎症组26.7％。3组血清PSA 平均值分别为(2.3830±0.8350)ng/ml、(3.1571±0.6432)ng/ml及(7.1557±0.9110)ng/ml。轻、中度炎症组间PSA改变无明显差 异(P>0.05),而轻、中度炎症组与重度炎症组阃PSA变化均有显著差异(P<0.001和P<0.005)。非细菌性前列腺炎血清PSA升 高比细菌性前列腺炎更明显,两者有显著差异(P<0.05)。结论:慢性前列腺炎血清PSA浓度升高比例在50％左右,PSA可作为衡 量该疾病严重程度及判断治疗效果好坏的一个重要指标。Objective: To explore the changes in and role of serum prostate specific antigen (PSA) concentration in patients with chronic prostatitis in relation to the diagnosis and treatment. Methods: A total of 360 patients with chronie prostatitis, aged between 20 and 60 years with a mean age of 48 years,were enrolled into this study. Their serum concentration of PSA was determined. On the basis of WBC count in examination of prostatic secretion (EPS),the patients were diagnosed with mild infection subgroup (WBC<10/HP) ,moderate infection subgroup (10/HP≤WBC <30/HP) and severe subgroup (WBC≥30/HP). The alterations in PSA concentration were compared among the three subgroups. EPS bactrial culture was performed in 180 patients. Results:Serum PSA level was increased in 46. 7% of the all subjects,of which 10% was in the mild subgroup; 10% in the moderate;26% in the severe. The mean serum concenrations of PSA in the three subgroups were (2. 3830±0. 8350) ng/ml, (3. 1571±0. 6432)ng/ml and (7. 1577±0. 9110) ng/ml,respectively. Between the mild and moderate subgroups , there was no significant difference in the serum PSA levels (P>0. 05) , whereas they were significantly different between the moderate and severe subgroups (P<0. 05) Serum PSA was increased more remarkably in non-bacterial prostatitis than in bacterial prostatitis with a significant diiference (P<0. 05). Conclusions: The serum PSA concentration was increased in 50% of the patients with chronic prostalitis. Therefore, PSA would be regarded as an important indicator to verify severity of the disease and to evaluate the curative effectiveness.

关 键 词：前列腺炎 前列腺特异抗原 治疗结果 

分 类 号：R697.33[医药卫生—泌尿科学]