福辛普利和氯沙坦对糖尿病伴白蛋白尿患者尿转化生长因子-β_1排泄的影响  

Effects of fosinopril and losartan on urinary TGFβ_1 excretion in diabetics with albuminuria

作　　者：叶山东[1] 荆春艳[1] 范艾红[1] 陈燕[1] 

机构地区：[1]安徽省立医院内分泌科,合肥230001

出　　处：《中国临床保健杂志》2005年第1期6-8,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省自然科学基金资助课题 (0 10 4 1181)

摘　　要：目的　观察血管紧张素转化酶抑制剂 (ACEI)———福辛普利和血管紧张素Ⅱ受体拮抗剂(ARB)———氯沙坦对糖尿病伴白蛋白尿患者尿转化生长因子 - β1(TGF - β1)排泄的影响 ,探讨其保护肾脏的可能机制。方法　 6 0例伴白蛋白尿的糖尿病患者被随机分为福辛普利组 (n =31)和氯沙坦组 (n =2 9) ,观察 3个月。结果　与治疗前基础值相比 ,两组患者经福辛普利或氯沙坦治疗 3个月后 ,尿TGF - β1/尿肌酐比值均较治疗前下降 ,差异有统计学意义 (P <0 .0 5 ) ;两组治疗前后尿TGF - β1/尿肌酐比值无差异 ,P >0 .0 5 ;尿白蛋白/尿肌酐比值也明显降低 ;福辛普利组 2例干咳 ,未见其它不良反应。结论　ACEI和ARB对糖尿病肾病有保护作用 ,其机制部分可能与下调TGF -Objective To observe the effects of angiotensin converting inhibitor(ACEI) - fosinopril and angiotensin Ⅱ receptor blocker (ARB)-losartan on urinary TGFβ 1 excretion in diabetics with albuminuria and explore their renoprotective mechanism.Methods 60 diabetics with albuminuria were divided into randomly fosinopril group(n=31) and losartan group (n=29) for three month observation.Results ①Compared with the basal levels, urinary TGFβ 1 /urinary creatinine ratio in both groups all decreased significantly, P<0.05; ②Urinary TGFβ 1 /urinary creatinine ratio in both groups had no marked difference before and after treatment between two groups, P>0.05; ③Urinary albumin /urinary creatinine ratio in two groups also decreased significantly after three month observation; ④Two patients in fosinopril group had dry cough, other side-effects didn't occur in two groups.Conclusion ACEI and ARB have renoprotective effect in patients with diabetic nephropathy, their renoprotective mechanisms may be related to partly the down-regulation of TGFβ 1 effects.

关 键 词：糖尿病肾病 转化生长因子-Β1 福辛普利 氯沙坦 

分 类 号：R587.2[医药卫生—内分泌]