卵巢早衰患者外周血T细胞亚群及SOD活性观察  

THE INVESTIGATION OF T CELL SUBSETS AND SUPEROXIDE DISMUTASE IN PATIENTS COITH PREMATURE OVARIAN FAILURE

作　　者：王瑜 曹缵荪 翁其亮[2] 毛文军[1] 高艳平 杨建业[2] 

机构地区：[1]西安医科大学第一临床医学院妇产科学教研室,西安710061 [2]西安医科大学测试中心

出　　处：《西安医科大学学报》1993年第2期109-111,118,共4页Journal of Xi'an Medical University(Chinese)

摘　　要：作者观察了12例卵巢早衰(POF)病人外周血中T细胞亚群的变化,同时对10例患者进行了红细胞中超氧化物歧化酶(SOD)活性测定。发现患者T_3、T_4、及T_4/T_8比值均低于对照组,同时SOD活性降低。提示:POF患者T细胞增殖及分化功能受抑制,免疫调节紊乱,抗氧化能力低下。因此,测定T细胞亚群及SOD活性对POF的病因探讨及诊断、治疗有一定价值。The change of T cell subsets of peripheralblood were tested in 12 patients with prematureovarian failure (POF), among them 10 patients superoxide dismutase (SOD) activity in erythrocytewas also tested. The results showed that the num-ber of T_3, T_4 cells T_4/T_8 ratio and SOD activitywas significantly lower in patients with POF thanin normal controls, which indicated that the func-tion of proliferation and differentiation of T lym-phocyte was inhibited, the immunoregulation wasinbalanced and the ability of resistance to lipid per-oxidation was lower in patients with POF. There-fore, the results suggests that T cell subsets andSOD activity testing in patients with POF have val-ue in the investigation of the cause of the deseaseas well as in the diagnose and treatment.

关 键 词：卵巢早衰 T细胞 超氧物歧化酶 

分 类 号：R711.750.3[医药卫生—妇产科学]