Polarographic Studies on Associations of Midecamycin and Chloroquine with Hydrogen Peroxide  

作　　者：LINing SONGJun-feng XUMao-tian ZHANGYa 

机构地区：[1]InstituteofAnalyticalScience,NorthwestUniversity,Xi＇an710069,P.R.China [2]DepartmentofChemistry,SuideTeachers′School,Suide718000,P.R.China

出　　处：《Chemical Research in Chinese Universities》2005年第1期32-35,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of P.R.China(No.2 0 4 75 0 4 3) and the Natural Science Foun-dation of Shaanxi Province(No.2 0 0 2 B0 1)

摘　　要：The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography. In a 0.15 mol/L KH 2PO 4-NaOH(pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1∶1, and the apparent association constant is 7.18. While in a 0.04 mol/L NH 3·H 2O-NH 4Cl(pH 9.5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1∶1 and 45.4, respectively. The formation of the association complexes stabilizes H 2O 2 and results in the accumulation of H 2O 2, which is baneful to human body.The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography. In a 0.15 mol/L KH 2PO 4-NaOH(pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1∶1, and the apparent association constant is 7.18. While in a 0.04 mol/L NH 3·H 2O-NH 4Cl(pH 9.5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1∶1 and 45.4, respectively. The formation of the association complexes stabilizes H 2O 2 and results in the accumulation of H 2O 2, which is baneful to human body.

关 键 词：MIDECAMYCIN Chloroquine phosphate Hydrogen peroxide Association Linear-potential scan polarography Reactive oxygen species 

分 类 号：R978.1[医药卫生—药品] R917[医药卫生—药学]