Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action  

作　　者：YongCHENG Li-hongSHEN Jun-tianZHANG 

机构地区：[1]InstituteofMateriaMedica,PekingUnionMedicalCollegeandChineseAcademyofMedicalSciences,Beijing100050,China

出　　处：《Acta Pharmacologica Sinica》2005年第2期143-149,共7页中国药理学报（英文版）

摘　　要：In the present paper,we overview the discovery of new biological activities induced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure;espe- cially Rg1,as one small molecular drug,can increase proliferation and differentia- tion of neural progenitor cells in dentate gyrus of hippocampus of normal adult mice and global ischemia model in gerbils.This finding has great value for treat- ment of Alzheimer's disease and other neurodegenerative disorders which is char- acterized by neurons loss.Increase of expression of brain derived neurotrophic factor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibition of apoptosis and calcium overload are also important neuron protective factors. Rgl and Rbl have common effects,but there are some differences in pharmacol- ogy and mechanism.These differences may attribute to their different chemical structure.Rg1 is panaxtriol with two sugars,while Rb1 is panaxtriol with four sugars.In the present paper,we overview the discovery of new biological activities induced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure;espe- cially Rg1,as one small molecular drug,can increase proliferation and differentia- tion of neural progenitor cells in dentate gyrus of hippocampus of normal adult mice and global ischemia model in gerbils.This finding has great value for treat- ment of Alzheimer's disease and other neurodegenerative disorders which is char- acterized by neurons loss.Increase of expression of brain derived neurotrophic factor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibition of apoptosis and calcium overload are also important neuron protective factors. Rgl and Rbl have common effects,but there are some differences in pharmacol- ogy and mechanism.These differences may attribute to their different chemical structure.Rg1 is panaxtriol with two sugars,while Rb1 is panaxtriol with four sugars.

关 键 词：GINSENG ginsenoside-Rg1 ginsenoside-Rb1 learning memory neural progenitor cells apoptosis immunity synaptic plasticity muscarinic cholinergic receptor long-term potentiation 

分 类 号：R96[医药卫生—药理学]