Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats  

Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats

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作  者:Shu-junXU ZhongCHEN Li-junZHU Hai-qingSHEN Jian-hongLUO 

机构地区:[1]DepartmentofNeurobiology,ZhejiangUniversitySchoolofMedicine,Hangzhou310031,China

出  处:《Acta Pharmacologica Sinica》2005年第2期177-180,共4页中国药理学报(英文版)

基  金:Project supported by Key National Basic Research Program of China(№ G2002CB-713808);Outstanding Cross-Century Faculty Grant of the Ministry of Education of China;the National Natural ScienceFoundation of China(№ 30270436 and 30371638)

摘  要:Aim:To examine the basic expression levels of N-methyl-D-aspartate(NMDA) receptor NR 1 and NR2B subunits in six brain regions of Sprague-Dawley(SD)rats with different visual recognition memory.Methods:Rats were tested by a novel- object-recognition model and grouped into the high and the low visual recogni- tion memory groups.The expression levels of NR1 and NR2B subunits in the cortex,hippocampus,striatum,amygdala,diencephalon,and olfactory bulb were measured by semiquantitative immunoblotting.Results:The NR1 and NR2B subunit protein levels in the hippocampus of the high visual recognition memory group were 35.9%(P<0.01)and 53.4%(P<0.05)higher respectively than those in the low group.In addition,the NR2B level in the striatum in the high visual recognition memory group was 25.0%(P<0.05)higher than that in the low one. However,no significant difference was found in the levels of the subunits be- tween the two groups in other brain regions.Conclusion:The visual recognition memory in rats is related to the basic expression level of NMDA receptor NR1/ NR2B subtype in the hippocampus and striatum.Aim:To examine the basic expression levels of N-methyl-D-aspartate(NMDA) receptor NR 1 and NR2B subunits in six brain regions of Sprague-Dawley(SD)rats with different visual recognition memory.Methods:Rats were tested by a novel- object-recognition model and grouped into the high and the low visual recogni- tion memory groups.The expression levels of NR1 and NR2B subunits in the cortex,hippocampus,striatum,amygdala,diencephalon,and olfactory bulb were measured by semiquantitative immunoblotting.Results:The NR1 and NR2B subunit protein levels in the hippocampus of the high visual recognition memory group were 35.9%(P<0.01)and 53.4%(P<0.05)higher respectively than those in the low group.In addition,the NR2B level in the striatum in the high visual recognition memory group was 25.0%(P<0.05)higher than that in the low one. However,no significant difference was found in the levels of the subunits be- tween the two groups in other brain regions.Conclusion:The visual recognition memory in rats is related to the basic expression level of NMDA receptor NR1/ NR2B subtype in the hippocampus and striatum.

关 键 词:N-methyl-D-aspartate receptors NR1 subunit NR2B subunit Western blotting visual recognition memory 

分 类 号:R971[医药卫生—药品]

 

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