Clinical investigation on diagnostic value of interferon-γ, interleukin-12 and adenosine deaminase isoenzyme for tuberculous pleurisy  

作　　者：GAOZhan-cheng TIANRui-xue 

机构地区：[1]DepartmentofRespiratoryMedicine,PekingUniversityPeople＇sHospital,Beijng100044,China [2]DepartmentofRespiratoryMedicine,PekingUniversityPeople＇sHospital,Beijng100044,China

出　　处：《Chinese Medical Journal》2005年第3期234-237,共4页中华医学杂志（英文版）

摘　　要：The proportion of tuberculous pleurisy among all pleurisy cases is 49.6% andis obviously increasing. However, malignant pleural effusion (29.6% of cases) also accounts for asignificant percentage of pleural diseases. Therefore, tuberculous pleurisy and malignant pleurisyare two main causes for pleural effusion. Because of their quite different prognosis and therapy, itis very important to differentiate them clearly. However, occasionally it is difficult to confirmthe diagnosis. Determination of adenosine deaminase (ADA) in pleural effusion has been confirmed asa useful supplemental diagnostic index for tuberculous pleurisy. However, ADA_2 as a major isoenzymeincreasing in tuberculous pleurisy has not been well investigated in China so far. On the otherhand, interferon- γ (IFN-γ) in tuberculous pleural effusion had been considered as a diagnosticmarker of tuberculous pleurisy. In this study, the concentration of IFN- γ and interlukin-12(IL-12), as well as the activity of ADA and ADA_2 in pleural effusion were measured in order toinvestigate their changes in tuberculous and malignant effusion, and find out the best marker fordiagnosis of tuberculous pleurisy.The proportion of tuberculous pleurisy among all pleurisy cases is 49.6% andis obviously increasing. However, malignant pleural effusion (29.6% of cases) also accounts for asignificant percentage of pleural diseases. Therefore, tuberculous pleurisy and malignant pleurisyare two main causes for pleural effusion. Because of their quite different prognosis and therapy, itis very important to differentiate them clearly. However, occasionally it is difficult to confirmthe diagnosis. Determination of adenosine deaminase (ADA) in pleural effusion has been confirmed asa useful supplemental diagnostic index for tuberculous pleurisy. However, ADA_2 as a major isoenzymeincreasing in tuberculous pleurisy has not been well investigated in China so far. On the otherhand, interferon- γ (IFN-γ) in tuberculous pleural effusion had been considered as a diagnosticmarker of tuberculous pleurisy. In this study, the concentration of IFN- γ and interlukin-12(IL-12), as well as the activity of ADA and ADA_2 in pleural effusion were measured in order toinvestigate their changes in tuberculous and malignant effusion, and find out the best marker fordiagnosis of tuberculous pleurisy.

关 键 词：interferon- γ interleukdn-12 tuberculous pleurisy 

分 类 号：R521.7[医药卫生—内科学]