AG490对人淋巴细胞增殖过程中细胞因子分泌的作用  

Effects of AG490 on the Production of Cytokines in Human Lymphocyte Proliferation

作　　者：蔡伟忠[1] 王彬[1] 

机构地区：[1]福建医科大学附属协和医院泌尿外科,福州350001

出　　处：《福建医科大学学报》2005年第1期38-40,共3页Journal of Fujian Medical University

摘　　要：目的　探讨 AG4 90作为免疫抑制剂的可能性及其基本作用机制。　方法　应用不同方法 (PHA、IL -2、ML C)诱导人淋巴细胞产生增殖 ,观察在不同干预剂 (AG4 90、Cs A、FK5 0 6 )作用下人淋巴细胞增殖过程中细胞因子 (IL- 2、IL- 6、IFN- γ)分泌的变化。　结果　 AG4 90在体外实验中 ,对于多种条件引起人淋巴细胞 (T、B混合存在 )增殖反应中 IL- 2、IFN- γ的分泌可以起到抑制作用 ,但对于 IL- 6分泌无抑制作用。　结论　 AG4 90有可能是一种潜在的免疫抑制剂。Objective To evaluate the possibility and prospect of the AG490 as a potential immunosuppressor and to explore its basic mechanism. Methods Human peripheral blood lymphocyte(both T and B) that come from healthy donors has been cultured with PHA, IL-2 or MLC. ELISA kits has been used to detect the concentration of IL-2, IFN-γ and IL-6 in different culture systems with the tyrphostin(AG490), CsA or FK506. Results IL-2 and IFN-γ but not IL-6 production have been suppressed by AG490 as compare to the control group. Conclusion AG490 may be a potential immunosuppressor.

关 键 词：细胞活素类 淋巴细胞 免疫抑制剂 

分 类 号：R392[医药卫生—免疫学]