同型半胱氨酸及其相关酶基因多态性与糖尿病周围神经病变的关系  

Relationship of plasma homocysteine and gene polymorphism of homocysteine metabolism related enzyme with diabetic peripheral neuropathy

作　　者：孙磊[1] 陈丽[1] 任建民[1] 王德全[1] 郑秀英[2] 许玲[1] 

机构地区：[1]济南山东大学齐鲁医院内分泌科,250012 [2]济南山东大学齐鲁医院职工保健科,250012

出　　处：《中华内分泌代谢杂志》2004年第6期536-537,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：研究对象为 2型糖尿病 (DM )有周围神经病变组 (60例 )、2型DM无周围神经病变组 (4 6例 )和正常对照组 (5 0例 )。分别测定 3组血浆同型半胱氨酸 (Hcy) ,血清叶酸、维生素B12 水平及Hcy代谢关键酶亚甲基四氢叶酸还原酶 (MTHFR)的基因型。结果显示 ,高Hcy及低叶酸、维生素B12 水平与 2型DM患者伴发周围神经病变相关 ,而MTHFR的基因多态性只与DM有关而与DM周围神经病变无相关性。Sixty cases of type 2 diabetes with diabetic peripheral neuropathy (DPN), 46 cases of type 2 diabetes without DPN and 50 healthy persons were recruited. Plasma homocysteine (Hcy), serum folic acid, vitamin B 12 levels and the mutations of Hcy metabolism related enzyme-methyhenetetrahydrofolate reductase (MTHFR) were assayed in individuals in this study. The results showed that high Hcy, low folic acid and vitamin B 12 levels are related with DPN in the patients with type 2 diabetes. The mutation of MTHFR C677T is associated with diabetes, but not with DPN.

关 键 词：糖尿病周围神经病变 DM MTHFR 同型半胱氨酸 维生素B12 相关酶 多态性 酶基因 关键酶 水平 

分 类 号：R587.2[医药卫生—内分泌]