人参茎叶总皂苷对衰老小鼠的作用研究  

study on the anti-aging effect of total Ginsenosides of Gingseng on the skin of aging mice

作　　者：程俊霖[1] 周黎明[1] 朱玲[1] 杨云霞[1] 赵妍妍[1] 范爱兰[1] 

机构地区：[1]四川大学基础与法医学院药理教研室,成都610041

出　　处：《四川生理科学杂志》2004年第3期97-99,共3页Sichuan Journal of Physiological Sciences

基　　金：四川省科委基金 (No .0 2SY0 2 9 137)资助

摘　　要：目的 :观察人参茎叶总皂甙口服对皮肤的抗衰老作用。方法 :小鼠颈背部皮下每日注射D 半乳糖 ( 1 0 0 0mg/kg)造成衰老模型 ,同时灌胃 5 0mg/kg .d 1和 1 0 0mg/kg .d 1的人参茎叶总皂甙 ,42天后 ,测定全血中的过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH Px)活力 ;测定皮肤组织匀浆中的羟脯氨酸、超氧化物歧化酶(SOD)和丙二醛 (MDA)含量。结果 :1 0 0mg/kg .d 1人参茎叶总皂甙使衰老小鼠全血中CAT和GSH Px活力显著升高 ,皮肤组织匀浆中SOD活力显著升高 ,MDA含量降低 ;5 0mg/kg .d 1和 1 0 0mg/kg .d 1人参茎叶总皂甙均使衰老小鼠皮肤组织中羟脯氨酸含量升高 ,且与衰老模型组比较有显著性差异。结论 :人参茎叶总皂甙口服对DObjective: To investigate the anti aging effect of Ginsenosides on skin. Methods: The aging mice model was made by subcutaneous administration in cervix with a dose of D galactose(1000mg/kg)for 42 days. At the same time, the aging mice take Ginsenosides(50mg/kg.d 1 or 100mg/kg.d 1 ) orally. The activities of CAT and GSH Px in whole blood and SOD in skin, the amounts of MDA and hydroxyproline in skin were checked after 42 days. Results: Ginsenosides of 100mg/kg.d 1 can significantly increase activities of CAT and GSH Px in whole blood and SOD in skin tissue and decrease the amount of MDA in skin tissue. Ginsenosides of 50mg/kg.d 1 or 100mg/kg.d 1 can improve the amount of hydroxyproline in skin tissue of aging model mice. Conclusion: Ginsenoside has remarkable anti aging effect in skin on aging mice induced by D galactose.

关 键 词：人参茎叶总皂苷 人体衰老 小鼠 D-半乳糖 生物衰老 生物制剂 

分 类 号：R285[医药卫生—中药学]