肝毒清颗粒对细胞因子的调节的实验研究  

Study of the adjusting effect on cytokines by GanDuQing granule

作　　者：李晓冰[1] 李万平[1] 肖顺汉[1] 陈美娟[1] 李华[1] 李亮[1] 

机构地区：[1]泸州医学院药理教研室,泸州646000

出　　处：《四川生理科学杂志》2004年第3期102-104,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :观察肝毒清颗粒对急性肝损伤的保护作用。方法 :选用雄性Wistar大鼠 60只 ,随机分为 6组 ,即空白对照组、模型组、肝毒清颗粒大、中、小剂量组 ,乙肝宁阳性对照组。用硫代乙酰胺复制急性肝损伤模型。检测血清TNF α、IL 6水平。结果 :硫代乙酰胺急性肝损伤时 ,肝毒清颗粒能使血清TNF α、IL 6水平明显降低 ,与模型组比较差异有显著性 (P <0 .0 5 )。结论 :肝毒清颗粒能减少致炎细胞因子的生成 ,减轻致炎细胞因子的肝损害 。Objective: To observe the protective effect of GanDuQing granule on acute hepatic injury. Methods: Sixty male wistar rats were divided into 6 groups, namely normal control group, model group, GanDuQing large, middle, small dose groups and YiGanNing positive group. Acute hepatic injury induced by thioacetamide. The changes of blood serum TNF α、IL 6 level were measured. Results: TNF α、IL 6 levels were significantly lower than model group (P<0.05). Conclusion: GanDuQing granule can reduce the creation of causing inflammation cytokines. Lighten cytokines leading hepatic injury and protect the liver when the liver was injured.

关 键 词：肝毒清颗粒 细胞因子 调节作用 检测方法 中成药 

分 类 号：R285[医药卫生—中药学]