新一代广谱抗生素药物筛选靶点肽脱甲酰基酶的研究进展  

Peptide deformlase as a target for new generation of broad spectrum antimicrobial agents

作　　者：唐先兵[1] 司书毅[1] 张月琴[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《中国新药杂志》2004年第12期1093-1098,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30270042)

摘　　要：肽脱甲酰基酶(peptide deformylase,PDF)存在于所有原核生物中,是其生长、代谢、繁殖必不可少的关键酶,但不存在于人类与其他哺乳动物细胞内,因而被视为新一代广谱抗生素药物筛选的理想靶点。现介绍PDF的结构、功能、理化性质以及作为药物筛选靶点的优良特点,此外,还简单介绍该酶与其抑制剂相互作用机制和以该酶为靶点新药研究进展。Peptide deformylase (PDF) found in all prokaryocytes is an essential enzyme that in-volves in growth,metabolism and multiplication of bacteria,and is also considered to be one of the mostpromising targets leading to the introduction of a new generation of broad spectrum antibiotics.Thispaper reviews the structure,function,and characteristics of PDF as a potential target for novel antibi-otics.Moreover,the interaction of PDF with its respective inhibitors and the research advancement ofPDF as drug targets are addressed.

关 键 词：肽脱甲酰基酶 广谱抗生素 抗菌药物筛选靶点 

分 类 号：R965.1[医药卫生—药理学] R978[医药卫生—药学]