免疫治疗原因不明习惯性流产后外周血T淋巴细胞亚群的变化  

The Changes of T Lymphocytes Sub-types in Unexplained Recurrent Spontaneous Aborti on Women after Immunotherapy

作　　者：陈巧儿[1] 秦卫兵[1] 叶嘉玲[1] 杨宁[1] 王一峰[1] 曾少颜[1] 许玉芳[1] 欧汝强[1] 

机构地区：[1]广东省计划生育科学技术研究所,广东广州510600

出　　处：《实用妇产科杂志》2005年第2期84-86,共3页Journal of Practical Obstetrics and Gynecology

基　　金：广东省计划生育委员会科研基金资助 (2 0 0 1 0 3)

摘　　要：目的:探讨原因不明习惯性流产患者外周血T淋巴细胞亚群在主动和被动免疫治疗前后的变化。方法:采用流式细胞仪对2 5例被动免疫治疗和38例主动免疫治疗的原因不明性习惯性流产患者作治疗前后外周血T淋巴细胞亚群含量对比,并选择2 0例正常妊娠者作对照组。结果:①被动与主动免疫组治疗前后CD3+细胞无明显差异。②被动和主动组治疗后CD4 +细胞较治疗前有明显减少。③CD8+细胞在被动免疫治疗和主动免疫治疗后较治疗前有明显升高。④CD4 +/CD8+比率在被动免疫治疗和主动免疫治疗后较治疗前明显下降。结论:主动和被动免疫治疗后,外周血T淋巴细胞亚群有了明显变化,更利于妊娠发展。Objective: To investigate the changes of T lymphocytes sub-types in unexplained recurrent spontaneous abortio n women before and after initiative immunotherapy and passiv e immunotherapy.Methods: Flow Cytometry was used to measu re T lymphocytes sub-types of unexplained r ecurrent spontaneous abortion women b efore and after 38 initiative immunotherap y and 25 pass ive immunotherapy, and 20 normal pregnant women were taken as control. Results: ①There are no significant changes in CD3+ cells before and after the initiat ive and passive immunotherapy.② CD4+ cells decreased significantly after both initiative and passive immunother apy . ③While CD8+ cellsincreased significant ly after both initiative and passive imm unotherapy. ④ CD4+/CD8+ ratio dropped gr eatly after both initiative an d passive immunoth erapy. Conclusions: T lymphocytes sub-types in URSA wom en cha nged markedly after both initiative and passive immunotherapy,in favor of sconce ption.

关 键 词：习惯性流产 T淋巴细胞亚群 被动免疫 主动免疫 

分 类 号：R714.21[医药卫生—妇产科学]