高等植物中蛋白磷酸酶2C的结构与功能  

The Structure and Function of Protein Phosphatase 2Cs in Higher Plants

作　　者：胡学博[1,2] 宋凤鸣[1] 郑重[1] 

机构地区：[1]浙江大学农业与生物技术学院植保系,水稻生物学国家重点实验室 [2]中国科学院微生物研究所,北京100080

出　　处：《细胞生物学杂志》2005年第1期29-34,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No. 30170598)~~

摘　　要：蛋白质磷酸化/去磷酸化是生物信号级联传递的重要方式之一,主要通过生化性质互为对立的蛋白激酶和蛋白磷酸酶实现。蛋白磷酸酶2C(PP2C)是蛋白磷酸酶的一个分支, 其生化性质、蛋白质组成与结构都和其他磷酸酶显著不同,但都在生物信号传递中扮演重要角色。高等植物中PP2C广泛参与脱落酸(ABA)的各种信号途径,包括ABA诱导的种子萌发/休眠、保卫细胞及离子通道调控和气孔关闭、逆境胁迫等。PP2C也多样地参与植物创伤反应、生长发育以及抗病性等各个途径。作为大多数信号途径的负调控因子,PP2C能直接与激酶结合,与其他调控蛋白结合,以及直接与DNA结合调控相关基因的表达。Protein phosphorylation and dephosphorylation, which are mainly done by protein kinases andphosphatases, two kinds of enzymes possessing converse functions, are most important aspects of signal transduc-tion pathways in all kinds of organisms. Protein phosphatase 2Cs (PP2Cs) are a subfamily of protein phosphatasesand their biochemical properties and protein structures distinguish themselves from any other subgroups. PlantPP2Cs have been demonstrated to play important roles in abscisic acid (ABA)-activated multiple signal transductions,such as ABA-induced seed dormancy/germination, guard cell closure, ion tunnel regulation and stress acclimation.Meanwhile, plant PP2Cs have also been shown to be involved in signaling in wound response, development andpathogen resistance. As negative regulatory factors of many signaling events, PP2Cs can interact with kinases, otherregulatory proteins, or directly combine with DNA to control expression of corresponding genes.

关 键 词：蛋白磷酸酶 信号途径 创伤反应 生物信号 相关基因 调控蛋白 蛋白激酶 高等植物 生化性质 结构与功能 

分 类 号：Q946[生物学—植物学]