高敏C反应蛋白与代谢综合征组分及靶器官损害的关系  

Association of the serum levels of high-sensitivity C reactive protein and components and target organ damage in patients with metabolic syndrome

作　　者：聂海[1] 祝之明[1] 闫振成[1] 倪银星[1] 赵志钢[1] 张刚[1] 杨华[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所高血压内分泌科第三军医大学高血压代谢病中心重庆市高血压研究所,重庆400042

出　　处：《中华心血管病杂志》2004年第12期1113-1117,共5页Chinese Journal of Cardiology

摘　　要：目的 探讨高敏C反应蛋白(hs-CRP)与代谢综合征组分及其靶器官损害的关系。方法 589例高血压、糖尿病或代谢综合征患者用免疫散射速率比浊法检测血清hs-CRP,分析hs-CRP与血脂、血糖、血压、腹围的关系;同时测定了299例患者颈动脉内-中膜厚度(IMT)、217例左室质量指数(LVMI)和443例尿白蛋白排泄率(UAER)作为判断是否存在代谢综合征靶器官损害的指标,分析hs-CRP与IMT、LVMI和UAER的关系。结果 血清hs-CRP水平随着代谢综合征组成成分数量的增加而升高,当其组成成分≥3个时,hs-CRP水平明显升高。相关分析表明hs-CRP浓度与甘油三酯、腹围、收缩压、舒张压、空腹血糖呈正相关,与高密度脂蛋白胆固醇呈负相关;血清hs-CRP水平与IMT、LVMI和UAER呈正相关关系,当hs-CRP水平升高时,可增加代谢综合征靶器官损害的程度和范围。结论 血清hs-CRP水平不仅与代谢综合征组成成分相关,而且与其靶器官损害程度密切联系。Objective The purpose of this study was to determine the association of the serum levels of high-sensitivity protein (hs-CRP) and components and target organ damage in patients with the metabolic syndrome (MS). Methods Total 589 participants were included in this study. MS criteria was defined by modified NCEP-ATPⅢ. Serum hs-CRP, fasting lipids and blood glucose (FPG), blood pressure, and waist circumference, left ventricular mass index (LVMI) , intima-media thickness(IMT) and urinary albumin excretion rate (UAER) were measured in all the participants. Results Increasing numbers of the MS components resulted in higher serum levels of hs-CRP (x2 = 178.4, P < 0.001). Especially, baseline level of hs-CRP for those with 3 or more MS components was much higher than that for those with 2 or less MS components. Similar finding was observed a parallel change between MS components and its numbers of target organ damage. Moreover, hs-CRP level was highly significant positive correlated with TG, waist circumference, SBP, DBF, FPG, and a significant negative correlation was observed between hs-CRP and HDL-C. Apart from this, there was a statistically significantly positive correlation between hs-CRP and IMT, LVMI and UAER (P < 0. 01). Conclusion The results indicated that serum hs-CRP level was closely related to the components and its target organ damage in patients with MS.

关 键 词：hs-CRP 代谢综合征 靶器官损害 血清 IMT UAER 高敏C反应蛋白 组成成分 水平 负相关 

分 类 号：R589[医药卫生—内分泌]