原发性高血压心肌超声声学密度及部分血管活性肽水平变化的研究  

A Study on Changes of Cardiac Acoustic Densitometry and Partial Plasma Vasoactive Peptides in Essential Hypertension

作　　者：黄晓真[1] 张梅[1] 张运[1] 

机构地区：[1]山东大学齐鲁医院心内科,山东省济南市济南槐荫医院250012

出　　处：《中国循环杂志》2004年第6期426-429,共4页Chinese Circulation Journal

摘　　要：目的 :应用超声声学密度技术探讨原发性高血压患者心脏心肌组织密度的变化 ,分析原发性高血压部分血管活性肽心钠素、脑钠素、内皮素 1、降钙素基因相关肽、胰岛素样生长因子 1(IGF 1)水平的变化规律及其与心肌组织密度的关系。　　方法 :将入选对象 90例 ,分为对照组 3 0例 ,无左心室肥厚组 3 0例及左心室肥厚组 3 0例 ,应用超声声学密度技术测量左心室心肌不同切面的平均声学密度值 (AII % ) ;测量心钠素、脑钠素、内皮素 1、降钙素基因相关肽、胰岛素样生长因子 1水平 ,分析其变化规律及与心肌声学密度的关系。　　结果 :无左心室肥厚组各室壁AII%较对照组有增高趋势 ,但差异无显著性意义 (P >0 0 5 ) ;左心室肥厚组四腔心切面观室间隔AII %较对照组显著性升高 (P <0 0 5 ) ,胸骨旁左心室长轴切面观室间隔AII %较对照组显著性升高 (P <0 0 5 ) ,余室壁AII %较对照组均有增高趋势 ,但差异无显著性意义 (P >0 0 5 ) ;而无左心室肥厚组和左心室肥厚组各切面室壁的平均声学密度值之和较对照组有显著性升高 (P <0 0 5 )。心钠素、脑钠素、内皮素 1、胰岛素样生长因子 1在无左心室肥厚组有增高的趋势 (P >0 0 5 ) ,在左心室肥厚组显著性升高 (P <0 0 5 )。Objective:To investigate the changes of heart tissue characteristaics of essential hypertension (EH) , ard analyse its partial plasma vasoactive peptides. Methods: All the selected subjects were divided into 3 groups: group A (normal subjects) , group B (EH without left ventricle hypertrophy and group C (EH with left ventricle hypertrophy) .Corrected acoustic densitometry (AII%) was examined by echocardiography.The levels of partial plasma vasoactive peptides in EH pationts were analysed. Results: In contrast to group A there was an increased tendency of AII% for EH heart walls in group B ( p >0 05) . The AII% of interventricular septa were significantly higher ( p <0 05) in group C,than group A. There was also an increased tendency of AII% for other heart walls in group C. The total AII% of all heart walls was significantly higher ( p <0 05) in group B and C. In contrast to group A there was an increased tendency of plasma levels of ANP,BNP, ET 1、and IGF 1 in group B ( p >0 05) ,but the tandency was more significantly in group C ( p <0 05) .The plasma level of CGRP in group B and group C significantly decreased ( p <0 05) ,but even in group C lower than in group B . Conclusions: The AII% in EH patients is high and even higher in group C ( p <0 05) .The levels of the partial plasama vasoactive peptides are correlated with AII% in EH patients.

关 键 词：声学密度 左心室肥厚 对照组 原发性高血压 超声 脑钠素 降钙素基因相关肽 压心 显著性 水平 

分 类 号：R544.1[医药卫生—心血管疾病] R541[医药卫生—内科学]