甘肃省SARS抗体血清流行病学调查  

Sero-epidemiological characteristics of antibody to SARS-associated coronavirus in Gansu Province

作　　者：于德山[1] 付士红[2] 孟蕾[1] 蒋建祥[1] 王炳涛[1] 王健[1] 王力华[2] 何英[2] 梁国栋[2] 

机构地区：[1]甘肃省疾病预防控制中心急性传染病防制科,兰州730000 [2]中国疾病预防控制中心病毒病预防控制所病毒基因工程国家重点实验室

出　　处：《中华实验和临床病毒学杂志》2004年第4期325-327,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：国家生物高技术 863项目 (2 0 0 3AA 2 0 840 5 )

摘　　要：目的　了解甘肃省严重急性呼吸综合征 (SARS)患者、密切接触者和正常人群血清SARS冠状病毒特异性IgG抗体水平。方法　利用酶联免疫吸附试验 (ELISA)法检测SARS病毒IgG抗体水平。检测对象包括甘肃省 9例SARS患者的急性期和 (或 )恢复期系列血清 ,110 9例直接护理SARS患者的医生、护士、实验室检测人员、疾控人员和曾与患者有接触的人员以及 978例正常人血清。结果9例临床诊断病例SARS冠状病毒特异性IgG抗体中 6例为阳性 ,疾病恢复后 12个月血清抗体仍为阳性 ;密切接触者 1例特异性IgG抗体阳性 ;正常人 3例特异性IgG抗体阳性。结论　病例抗体阳性符合临床诊断 ,密切接触者和正常人的抗体阳性数较低 。Objective To study the levels of SARS-associated coronavirus IgG antibody of SARS patients, people who closely contacted SARS patients and normal subjects in Gansu province. Methods The levels of SARS-associated coronavirus IgG antibody were measured by ELISA. The material included acute and (or) recovery period sera of 9 SARS patients, sera from 1 109 doctors and nurses closely contacted with SARS patients, laboratory workers, personnel for disease control and prevention, persons who contacted SARS patients, and sera from 978 normal subjects. Results SARS coronavirus IgG antibody was detected positive in 6 of the 9 patients, it was still positive in the sera twelve months after recovery; 1 of the closely contacted persons and 3 normal subjects were found positive. Conclusion The positive rate of SARS coronavirus IgG antibody of patients was consistent with the clinical diagnosis. The low positive rate of the persons who closely contacted SARS patients and normal subjects suggests that SARS probably had no subclinical infection.

关 键 词：特异性IGG抗体 抗体阳性 密切接触者 正常人 血清流行病学调查 患者 SARS冠状病毒 甘肃 隐性感染 血清抗体 

分 类 号：R181.3[医药卫生—流行病学]