术前静脉注射小剂量氟哌利多对患者心电图Q-T间期的影响  

Effect of low dose droperidol on Q-T interval

作　　者：沈伯雄[1] 黄文红[2] 周为民[1] 汪爱民[1] 黄雪花[1] 杭燕南[3] 

机构地区：[1]上海第二医科大学附属宝钢医院麻醉科,201900 [2]上海第二医科大学附属宝钢医院心功能科,201900 [3]上海第二医科大学附属仁济医院麻醉科,201900

出　　处：《中华麻醉学杂志》2004年第11期826-827,共2页Chinese Journal of Anesthesiology

摘　　要：目的 评估术前静脉注射小剂量氟哌利多的安全性。方法 拟行择期手术的患者60例,AsA Ⅰ-Ⅱ级,术前心电图无异常,随机分为三组,A组(氟哌利多0.05 mg·kg-1),B组(氟哌利多0.1 mg·kg-1)和C组(生理盐水5 ml),每组20例。用药前、后行12道心电图检查,比较三组用药前后心电图Q-T间期和Q-Tc的变化。结果 A、B组Q-T间期分别为(376±24)ms、(374±19)ms,与C组[(353±10)ms]比较差异无统计学意义(P>0.05);每组用药前、后比较Q-T间期和Q-Tc差异无显著性(P>0.05)。结论 患者术前静脉注射小剂量氟哌利多可安全用于预防术后恶心、呕吐。Objective To evaluate the safety of low dose droperidol given intravenously before surgery. Methods Sixty patients of both sexes with normal cardiopulmonary, hepato-renal and brain function aged 18-73 yrs undergoing elective surgery were randomly divided into 3 groups with 20 patients in each group : group A received droperidol 0.05 mg·kg-1 in normal saline 5 ml i.v.; group B droperidol 0.1 mg·kg-1 in normal saline 5 ml i.v. and group C normal saline 5 ml i.v. . Q-T interval was measured and Q-Tc calculated with 12 lead EKG before and 10 min after intravenous droperidol administration. SpO2 was maintained above 98% by nasal administration of O2 (3 L· min-1 ) .Results The Q-T interval after intravenous droperidol was (376 ±24) ms (group A) and (374 ±19) ms (group B) compared to (353±10 ) ms in group C ( P > 0.05) . There was no significant difference in Q-T interval and Q-Tc before and after intravenous droperidol in the three groups. Conclusion It is safe to give low dose droperidol before operation to prevent postoperative nausea and vomiting.

关 键 词：心电图 氟哌利多 术前 Q-T间期 患者 小剂量 静脉注射 结论 差异 显著性 

分 类 号：R614[医药卫生—麻醉学]