超临界抗溶剂技术在药物微粒化领域的研究进展  

Application of supercritical anti-solvent technology in production of pharmaceutical microparticles

作　　者：陈蓓怡[1] 于文利[1] 赵亚平[1] 

机构地区：[1]上海交通大学化学化工学院,上海200240

出　　处：《现代化工》2005年第2期17-20,共4页Modern Chemical Industry

基　　金：上海市纳米专项项目(0352nm105)

摘　　要：总结了超临界抗溶剂技术在微粉化药物和制备缓释药物微球方面的研究现状和发展。在药物微粉化方面,着重介绍了超临界辅助原子化法对水溶性药物的处理,包括该方法的原理、操作方法以及操作参数对产品性能的影响,证明该方法用于改善水溶性药物的微粉化具有良好的效果;在制备药物微球方面,重点介绍了不同操作条件和不同分子质量的载体、不同配比的复合载体对药物微球性能的影响以及表面活性剂在亲脂性及离子型药物微球制备中的应用,指出添加表面活性剂将更有利于得到该类药物的微球。The present research situation and development of drug micronization and embedment is summarized. It is especially discussed that the principle, operation process and effects of the operation parameters on the characteristic of the products when the hydrophilic drug micronized with the supercritical assisted atomization (SAA) which is an improvement on the supercritical anti-solvent (SAS) technology. It is also introduced that the embedment of hydrophobic drug into biodegradable materials with the use of surfactant as well as the effect of different molecular weight of carrier and different ratio of complex carrier on the characteristic of products is made. It is pointed out that the use of surfactant will improve the micronization of microparticles of the hydrophobic drugs.

关 键 词：超临界流体 抗溶剂 超临界辅助原子化法 药物 微细颗粒 微粉化 包埋 

分 类 号：TQ02[化学工程] TQ460