控制急性有机磷中毒惊厥药物的研究概况  

Advances in study of drugs controlling seizures in organophosphate poisoning

作　　者：刘黎[1] 孙金秀[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《中国工业医学杂志》2005年第1期47-49,共3页Chinese Journal of Industrial Medicine

基　　金：国家科技攻关计划课题 (编号 :2 0 0 1BA70 4B0 6)

摘　　要：急性有机磷中毒 (acuteorganophosphatepoisoning ,AOPP)后 ,常出现全身抽搐和惊厥的症状 ,如果处理不当会导致不可逆的脑损伤。惊厥主要是由AChE活性被抑制所致的胆碱能神经系统过度兴奋导致的 ,有证据表明惊厥的过程可能还与兴奋性氨基酸 (谷氨酸 )受体的激活有关。本文主要讨论了对急性有机磷中毒引起惊厥有治疗作用的药物 :苯二氮类药物、兴奋性氨基酸受体拮抗剂、BDZ受体的部分激动剂、可逆性胆碱酯酶的抑制剂及其他的一些药物 ,以供实验和临床研究参考。The main symptoms of acute organophosphate poisoning(AOPP)always are seizures followed by systemic convulsions that could lead to brain damage if uncontrolled.Seizures are believed to be due to hyperactivity of the cholinergic nervous system,that caused by inhibition of acetylcholinesterase(AChE).Some evidences even suggest that the seizure process might relate to the activation of excitatory amino acid receptors.The paper summarizes the effects of some anticonvulsant drugs,such as benzodiazepine(BDZ),antagonists of excitatory amino acid receptor,partial agonists of BDZ receptor,reversible AChE inhibitors etc.

关 键 词：急性有机磷中毒 惊厥 安定 

分 类 号：R595.4[医药卫生—内科学] R971.6[医药卫生—临床医学]