血红素加氧酶-1的研究进展  

Advances in studies on heme oxygenase

作　　者：李俊[1] 黄艳[1] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032

出　　处：《安徽医药》2005年第1期3-7,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目 (No 30 371 766)

摘　　要：血红素加氧酶 (hemeoxygenase ,HO)是一种最广泛存在的抗氧化防御酶 ,是热休克蛋白家族中的一个成员 ,可代谢血红素生成CO、胆红素和游离铁。在大多数组织内呈低水平表达 ,可被多种伤害性刺激包括血红素、高氧、缺氧、热休克、内毒素、过氧化氢、细胞因子、紫外线、重金属和NO等诱导产生高水平的表达。HO 1基因表达的调控主要发生在转录水平。HO 1具有抗炎抗氧化、抗凋亡、抗增生效应 ,但其保护作用的机制仍不是很清楚。HO 1的产生作为一种对伤害性刺激的适应性和保护性反应 ,与临床上一些相关疾病密切相关。有关此方面的研究现越来越多并且取得了重大的进展。本文就HO 1的产生、基因调控、功能及其与肺部和其他系统疾病的关联方面的研究现状作一综述。Heme oxygenase(HO) is a kind of antioxidative enzymes which is the rate-limiting enzyme of heme degradation and produces bilirubin, carbon monoxide(CO), and iron. It is expressed at a low level in most mammalian tissues and is highly induced by many factors which induce oxidative injury such as heme, hydrogen peroxide, ultraviolet radiation, heavy metals, hypoxia, hyperoxia, nitric oxide (NO), shear stress, endotoxin, cytokines, growth factors et al and protect against oxidative stress. It is found that HO-1 could protect people from a lot of diseases and its protective mechanism relates undoubtedly to various kinds of metabolites produced in catabolism, but the exact mechanism remains unknown. This article is an review mainly on the induction, function of HO-1 and the relationship between HO-1 and some diseases.

关 键 词：伤害性刺激 HO-1 血红素加氧酶-1 抗氧化 高氧 系统疾病 组织内 转录水平 基因调控 抗凋亡 

分 类 号：R341[医药卫生—基础医学]