电位滴定法测定克林霉素磷酸酯氯化钠注射液中氯化钠含量  

Potentiometric titration determination of sodium chloride in clindamycin phosphate and sodium chloride injection

作　　者：程云峰 王光华 宛小林 卢琳 

机构地区：[1]安徽省丰原药业无为药厂,安徽无为238300

出　　处：《安徽医药》2005年第1期40-41,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的　建立一种用电位滴定法测定克林霉素磷酸酯氯化钠注射液 (商品名 :恒新 ,以下简称恒新注射液 )中氯化钠含量的方法。方法　采用银电极为指示电极 ,以 0 1mol·L-1硝酸银为滴定剂 ,有电位滴定仪在常温下进行测定。结果　该方法测定线性范围为 9～ 90mg ,r=0 9999,加样平均回收率为 99 7% ,精密度RSD为 0 0 8%。结论　该法快速准确 ,无干扰 ,可用于恒新注射液质量控制。Aim Determination of sodium chloride in clindamycin phosphate and sodium chloride injection by potentiometric titration.Methods In the method,argent electrode a indicator electrode, 0.1 mol·L -1 silver nitrate as titrant ,determining at normal temperature. Results The calibrataion curve was linear in the range of 9～90 mg of diogenin with correlation coefficient of 0.999 9 ,the average recovery was 99.7%,the precision(RSD) was 0.08%. Conclusion This method is quick and accurate,noninterference, it may be adopted for quality control of clindamycin phosphate and sodium chloride injection.

关 键 词：克林霉素磷酸酯 氯化钠注射液 含量 RSD 电位滴定法 商品名 测定 滴定剂 平均回收率 银电极 

分 类 号：R927[医药卫生—药学]