冬虫夏草对肾性高血压大鼠血管重构的影响  

Effect of Codyceps Sinensis on Hypertensive Vascular Remodeling

作　　者：吴秀香[1] 李淑云[2] 马克玲[2] 安鼎伟[3] 

机构地区：[1]锦州医学院病理生理教研室,锦州121001 [2]锦州医学院机能中心实验室 [3]锦州医学院附属第一医院消化科

出　　处：《数理医药学杂志》2005年第1期46-47,共2页Journal of Mathematical Medicine

摘　　要：目的 :观察冬虫夏草对肾性高血压大鼠心肌肥厚、血管重构的影响。方法 :体重为 160～ 180 g健康雄性 Wistar大鼠随机分为对照组、高血压组及治疗组 ,于术后第 10天大鼠灌胃 (ig)冬虫夏草煎剂 2 ml,每日两次 (bid) ,连续 2 0天 ,观察冬虫夏草对心肌肥厚、血管重构的影响。结果 :冬虫夏草明显改善高血压大鼠血压、心肌肥厚及血管重构。结论 :冬虫夏草对肾性高血压有治疗作用。Objective: To observe the effect of Codyceps sinensis on hypertensive cardiac hypertrophy and vascular remodeling. Methods: Wistar rats were treated ig with Codyceps sinensis twice a day for 4 weeks. The effect of Codyceps sinensis on hypertensive cardiac hypertrophy and vascular remodling were investigated. Results: The increase of blood pressure in RH rats could be prevented significantly by treatment with Codyceps sinensis and it's cardiac hypertrophy and vascular remodeling was reversed. Conclusion: Codyceps sinensis has a curable role on renal hypertensive rats.

关 键 词：血管重构 冬虫夏草 肾性高血压 大鼠 心肌肥厚 观察 影响 体重 雄性 改善 

分 类 号：R544[医药卫生—心血管疾病] R282[医药卫生—内科学]