感染性休克患者血清细胞因子表达及其意义  

The expression and clinical significance of serum cytokines in patients with septic shock

作　　者：许长琼[1] 杨径[1] 

机构地区：[1]深圳市第二人民医院,广东深圳518029

出　　处：《中国感染控制杂志》2005年第1期18-20,共3页Chinese Journal of Infection Control

摘　　要：目的　探讨感染性休克患者血清肿瘤坏死因子 (INF) α ,白细胞介素 (IL) 6 ,IL 8的表达及意义。方法选择 5 6例感染性休克患者 ,将其分为感染性休克组与多器官功能障碍综合征 (MODS)组 ,另设 5 0例健康者为对照组。用酶联免疫吸附 (ELISA)法动态检测上述研究对象的血清INF α ,IL 6 ,IL 8含量 ,比较各组间的差异。结果感染性休克组及MODS组的血清细胞因子INF α ,IL 6 ,IL 8的表达均显著高于对照组 (均 P <0 .0 1) ,MODS组高于感染性休克组 (P <0 .0 1) ,且病死病例明显高于存活病例 (P <0 .0 5 )。IL 6与IL 8呈明显正相关。结论　血清细胞因子INF α ,IL 6 ,IL 8参与了感染性休克的发生、发展过程。动态监测血清细胞因子对于判断感染性休克患者病情的轻重 ,估计预后有一定价值。Objective To study the expression and clinical significance of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in patients with septic shock. Methods Fifty-six patients with septic shock were divided into septic shock group and multiple organ dysfunction syndrome (MODS) group, 50 healthy persons were selected as control group. Concentration values of TNF-α、IL-6、IL-8 were dynamicaly detected by ELISA method and were compared among control, septic shock and MODS groups. Results Cytokines concentration values in septic shock and MODS groups were higher than that of control group. Value of cytokines concentration of MODS group was higher than that of septic group. Conclusion The serum TNF-α、IL-6、IL-8 are involved with the occurrence and progress of septic shock. Dynamic monitor of serum cytokines plays a role in diagnosis of the severity of septic shock and its prognosis.

关 键 词：感染性休克 细胞因子 肿瘤坏死因子-Α 白细胞介素-6 白细胞介素-8 

分 类 号：R631.4[医药卫生—外科学]