黄体酮试用于64例腹部绞痛病人分析  

Trial of Progesterone in the Treatment of Abdomino-colic Patients

作　　者：胡灵群 周颖[1] 

机构地区：[1]浙江省中医院,杭州310006

出　　处：《现代应用药学》1993年第4期36-37,共2页

摘　　要：用20mg 黄体酮肌注对症治疗各种病因所致的腹部绞痛病人64例。治疗后1.5h 内,完全缓解52例,部分缓解6例,无效6例(9.38%),总有效率90.63%。腹痛开始缓解平均时间45.51±17.48 min。期间除轻度利尿外无明显副反应。不缓解组的急诊手术比为5/6,与有效组比较有高度显著性差异(P<0.01)。认为黄体酮的解痉止痛机理主要与松驰内脏平滑肌有关,因此在治疗腹部绞痛,权衡采用内科保守还是急诊手术时,可将黄体酮肌注作为一项试验性治疗手段。20mg progesterone intramuscular injection was used to treat 64 patients with abdomino-colic caused by various disease in the emergency wards.1.5 hour after the treatment, 52 cases were of complete relaxation,6 cases with Partial relaxation,and 6 cases(9.38%) without relaxation,the effective ratio was 90.63%.The average time of relaxation was 45.51 ±17.48 minutes.There was no apparent side effects besides slight natriuresis during this period.The ratio of erergency operation in the non-effective group was 5/6,and it was significently different from the effective group(P<0.01).The authors' opinion is that the spasmolysis and analgesis mechanism of progesterone is related to relaxation of visceral smooth muscles.In the colic treatment,the Progesterone imtramuscular injection can obviously be used as tenative measure for decision to take conservative treatment or emergency operation. This method could be further tested.

关 键 词：黄体酮 腹部绞痛 急腹症 

分 类 号：R969.4[医药卫生—药理学]