丙烯酰胺与葡萄糖烯丙基酰胺共聚水凝胶的合成与释药性能研究  

Synthesis and the Drug Release Properties of Poly(acrylamide-co-glycosylallylamide) Hydrogels

作　　者：李凌冰[1] 谭业邦[2] 孟建文[2] 

机构地区：[1]山东大学西校区药学院药剂教研室,济南250012 [2]山东大学化学与化工学院,济南250100

出　　处：《生物医学工程学杂志》2004年第6期960-963,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金 (2 990 40 0 3 );山东大学预研基金资助(2 13 10 0 5 13 10 0 81)

摘　　要：用葡萄糖内酯与烯丙基胺反应制备了葡萄糖烯丙基酰胺单体 (AAG) ,然后与丙烯酰胺和亚甲基双丙烯酰胺共聚得到含糖结构的水凝胶。以阿司匹林为模型药物 ,制备水凝胶缓释骨架片。通过对Peppas经验式中n值的详细考察 ,研究阿司匹林在不同骨架片中的释放度。证实骨架片中药物的释放是随着糖基单体的含量增加而减少。Sugar-containing monomer glycosylallylamide(AAG)was s yn thesized by allyl amine and δ-gluconolactone in dimethylformamide(DMF) solut ion。The sugar-based hydrogels were prepared by free radical crosslinking copol ymerization of AAG and acrylamide(AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate th at the drug release decreases with the increase of the sugar content of hydrogel .

关 键 词：骨架片 释药性能 阿司匹林 水凝胶 葡萄糖 释放度 药物 共聚 烯丙基 单体 

分 类 号：R318.08[医药卫生—生物医学工程]