ApoE基因多态性与冠心病患者抑郁情绪的关系  

ApoE Genotype and Depressive Symptoms in Patients with Coronary Heart Disease

作　　者：季卫东[1] 成俊祥[2] 赵国安[2] 吕风华[2] 杨瑞[2] 

机构地区：[1]四川大学华西医院心理卫生中心,610041 [2]新乡医学院,453000

出　　处：《中国心理卫生杂志》2005年第1期1-4,共4页Chinese Mental Health Journal

摘　　要：目的:了解ApoE基因多态性与冠心病患者抑郁情绪的关系。方法: 用聚合酶链反应扩增技术和限制性片段长度多态性技术(PCR-RFLP)对26例冠心病伴抑郁者、30例冠心病不伴抑郁者和30例健康对照组的载脂蛋白E基因(ApoE)进行分析,用汉密尔顿抑郁量表(HRSD)评定抑郁。结果: 冠心病伴抑郁组的ApoEε4等位基因频率显著高于对照组(P<0.05),而其它等位基因频率在各组中的差异无统计学显著性(P>0.05)。携带ε4等位基因者HRSD(因子分中的运动迟缓、绝望感分)、HAD(包括D因子分和A因子分)总分以及总胆固醇水平均高于非携带ε4等位基因的患者,但在认知损害、体重、睡眠障碍因子得分上的差异没有统计学显著性。结论: ApoE基因多态性与冠心病抑郁情绪有一定的关联,尤其是ApoEε4等位基因在冠心病患者抑郁情绪的发生中可能起重要作用。Objective:To investigate the relationship between apolipoprotein E (ApoE) genetype and the depressed symptoms in patients with coronary heart disease. Methods:The genotypes and alleles of apolipoprotein E gene in 26 depressed patients with coronary heart disease,30 non-depressed patients with coronary heart disease and 30 healthy control subjects were examined with the polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) technique.Meanwhile, the HRSD was completed by all 86 subjects. Results:The frequency of Apolipoprotein E epsilon 4 in depressed patients with coronary heart disease was more than that in normal subjects .Especially the total cholesterol, HRSD and HAD in patients with the apolipoprotein E epsilon 4 were significantly higher than those in patients without the apolipoprotein E epsilon 4. Conclusion:Our results support the polymorphisms of apolipoprotein E gene were associated with the depressed symptoms in coronary heart disease. Apolipoprotein E epsilon 4 may play a major role in the pathogenesis of depressed symptoms in patients with coronary heart disease.

关 键 词：APOE基因 多态性 冠心病 抑郁情绪 聚合酶链反应扩增技术 

分 类 号：R541.4[医药卫生—心血管疾病] R749.2[医药卫生—内科学]