益胃康胶囊对胃炎、胃溃疡模型鼠的胃粘膜修复作用研究  

Effects of Yiweikang Capsule on Recovery of Gastric Mucosa of Model Rats with Gastritis and Gastric Ulcer

作　　者：胡陵静[1] 杨敏[1] 胡小梅[1] 谢惠民[1] 陈古荣[2] 

机构地区：[1]重庆市中医院,重庆市400011 [2]重庆市中药研究院,重庆市400065

出　　处：《中国药房》2005年第3期178-180,共3页China Pharmacy

基　　金：重庆市卫生局基金资助项目 (渝卫200242号 )

摘　　要：目的 :探讨益胃康胶囊对胃炎、胃溃疡模型鼠的胃粘膜修复作用。方法 :将实验鼠分为阴性对照组 (生理盐水 )、益胃康胶囊(高、中、低剂量 )组和阳性对照组 (甲氰咪呱胶囊 ) ,观察益胃康胶囊灌服后对应激性胃溃疡小鼠、对乙醇所致和幽门结扎型胃溃疡大鼠的影响。结果 :与阴性对照组比较 ,益胃康胶囊组溃疡指数、胃酸、胃液量降低 ,尤以高剂量组降低更明显。结论 :益胃康胶囊口服给药对应激性溃疡、对乙醇型溃疡和幽门结扎型胃溃疡鼠模型具有预防作用 ,对胃炎、胃溃疡模型鼠的胃粘膜具有良好的修复作用。OBJECTIVE:To investigate the protective effects of Yiweikang(YWK)capsule on gastric mucosa of the model rats with gastritis and gastric ulcer.METHODS:The experimental rats were randomly divided into five groups:YWK high-dosage group,YWK moderate-dosage group,YWK low-dosage group,positive control group(treated with drenched cimeˉtidine capsule,0.1g/kg),and negative control group(provided with drenched isovolumic distilled water or sodium chloride)in order to observe the effects of YWK for excitable gastric ulcer in mice and gastric ulcer in rats induced by alcohol and pylorus-ligature.RESULTS:Compared with the negative controls,gastric acid,gastric juice and ulcer indices in YWK group declined,most significantly in high-dosage group.CONCLUSION:YWK in oral administration has preventive effects for excitable ulc_ er,alcohol induced ulcer and pylorus-ligature induced ulcer.It also can help the recovery of gastric mucosa of ulcer model rats.

关 键 词：益胃康胶囊 胃炎 胃溃疡 胃粘膜修复 

分 类 号：R285[医药卫生—中药学] R975[医药卫生—中医学]