野马追一般药理作用实验研究  

Experimental Study on General Pharmacologic Actions of Yemazhui

作　　者：周远大[1] 陈康[2] 何海霞[1] 江舟[3] 曾敏莉[1] 杨辉[1] 

机构地区：[1]重庆医科大学附属第一医院临床药理研究室,重庆市400016 [2]重庆医科大学应用技术学院,重庆市400016 [3]重庆医科大学附属第一医院药剂科,重庆市400016

出　　处：《中国药房》2005年第2期94-96,共3页China Pharmacy

摘　　要：目的 :探讨野马追的一般药理作用和毒性作用。方法 :选用大、小鼠进行自主活动、激怒反应、爬杆运动、心血管与呼吸系统以及急、慢性毒性试验。结果 :野马追对大、小鼠自主活动、激怒反应、爬竿运动、心血管与呼吸系统均无明显影响 ;小鼠灌服野马追后LD50 为225 6g(生药 )/kg(体重 ) ,95 %可信限为199 7～254 9g(生药 )/kg(体重 ) ,慢性毒性试验中未见明显毒性发生。结论 :野马追对鼠正常生理活动和各组织器官无明显影响。OBJECTIVE:To study the general pharmacologic actions and toxicity of Yemazhui.METHODS:The auˉtonomous movement,provoking response,climbing pole exercise,cardiovascular and respiratory reactions,acute and chronic toxicity tests were observed in rats and mice.RESULTS:Yemazhui had no obvious influence on autonomous movement,provok_ ing response,climbing pole exercise,cardiovascular and respiratory systems in rats and mice.LD 50 after Yemazhui ig was225.6g(herb)/kg(BW)with a95%confidence of199.7～254.9g(herb)/kg(BW)in mice.No toxic reaction was found in chronic toxi_ city test.CONCLUSION:Yemazhui has no obvious influence on normal physiological action and tissues and organs in animals.

关 键 词：野马追 心血管系统 呼吸系统 毒性作用 

分 类 号：R285.5[医药卫生—中药学] R965[医药卫生—中医学]