新癀片对荷S_(180)小鼠的肿瘤生长及免疫功能的影响  

Effects of Xinhuang Tablets on the Growth of Tumor and Immunologic Function in S_(180) Sarcoma-bearing Mice

作　　者：朱蔚云[1] 杨炜青[1] 阮小贞[1] 龙伟光[1] 梁敏仪[1] 庞竹林[1] 

机构地区：[1]广州医学院

出　　处：《中国药房》2005年第2期98-100,共3页China Pharmacy

摘　　要：目的 :探讨新癀片对荷S180 小鼠的肿瘤生长及免疫功能的影响。方法 :采用小鼠S180 实体瘤模型 ,以新癀片灌胃治疗 ,观察新癀片对荷S180 小鼠的瘤体比、抑瘤率、胸腺和脾脏的脏器系数及骨髓PCE微核率的变化。结果 :新癀片具有减少瘤体比、明显抑制肿瘤生长、增加脾重和外周血白细胞数目的作用 ,但对骨髓PCE微核率无明显影响。结论 :新癀片具有抑制S180 肿瘤生长和增强其细胞免疫的功能。OBJECTIVE:To study the effects of Xinghuang tablets on tumor growth and immunologic function in S 180 sarcoma-bearing mice.METHODS:The model of mice with S 180 sarcoma were given Xinhuang tablets intragastrically to obˉserve the effects on the ratio of tumor to body,the inhibition rate of tumor,the indices of the spleen and thymus,and the rate of micronuclei in PCE in bone marrow of the mice.RESULTS:The body weight of the mice with S 180 sarcoma was decreased;the growth of the tumor was inhibited;the weight of spleen was increased;the number of leucocyte of peripheral blood was raised(P<0.01);the rate of micronuclei in the bone marrow PCE could not be obviously affected.CONCLUSION:The immunologic function could be enhanced and the growth of tumor could be inhibited by Xinhuang tablets.

关 键 词：新癀片 肿瘤 免疫 微核率 

分 类 号：R965[医药卫生—药理学] R932[医药卫生—药学]