不稳定型心绞痛患者甲状腺激素水平与冠状动脉病变的关系  

The relationship study between plasma thyroid hormone in patients with unstable angina and the severity of coronary lesions

作　　者：薛书峰[1] 娄书花[1] 张桂清[1] 张守彦[1] 赵建华[1] 田利平[1] 李群生[2] 

机构地区：[1]洛阳市中心医院心内科,河南洛阳市471009 [2]河南省洛阳市中心医院放免科

出　　处：《中国心血管病研究》2005年第2期122-124,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨不稳定型心绞痛患者甲状腺激素水平与冠状动脉病变的关系。方法测定159例不稳定型心绞痛患者血浆游离三碘甲状腺原氨酸(FT3)、血浆游离甲状腺素(FT4)、血浆反三碘甲状腺原氨酸(rT3)和促甲状腺素(TSH)。根据冠脉病变记分分为轻、中、重三组,并与19例冠状动脉造影正常者对照,比较各组甲状腺激素水平,分析甲状腺激素水平与冠脉病变的相关性。结果159例不稳定型心绞痛患者中,重度冠状动脉病变组的血清FT3水平明显低于对照组(P<0.05),中、重度冠状动脉病变组的血清rT3水平均明显高于对照组(P<0.01)。血清FT3水平与冠状动脉病变记分呈负相关,r=-0.3942,P<0.01,血清rT3水平与冠状动脉病变记分呈正相关,r=0.4233,P<0.01。结论不稳定型心绞痛患者血清FT3水平降低,rT3水平升高,FT3和rT3的变化在一定程度上反映冠脉病变的严重性。Objective To evaluate the relationship between plasma thyroid hormone in patients with unstable angina and the severity of coronary lesions. Methods Serum levels of thyroid hormones ( free triiodothyronine , reverse riiodothyronine , free thyroxine , and thyroid-stimulating hormone) were measured in 159 patients with unstable angina. All of the 159 patients were divided into three groups according the score of the coronary lesions. 19 patients with normal coronary as control group. Serum levels of thyroid hormones in all groups were compared, and the relationship between plasma thyroid hormone and the severity of coronary lesions were studied. Results The mean level of the hormone FT3 decreased in the group of severe coronary lesions compared with control group(P<0.05=, the rT3 levels increased in the groups of middle and severe lesions compared with control group(P<.001=. we found a strong negative corelation between FT3 and the score of the coronary lesions(r=-0.,3942,P<0.01=, a strong positive corelation between rT3 and the score of the coronary lesions(r=0.4233, P<0.01=. Conclusion The study suggested that the level of FT3 decreased and the level of rT3 increased in patient with unstable angina. The change of FT3 and rT3 could reflect the severity of coronary lesions.

关 键 词：甲状腺激素 冠状动脉疾病 不稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]