3种非典型抗精神病药对精神分裂症患者精神症状和生活质量的影响  

Comparative Study on the Psychopathology and the Quality of Life of Schizophrenia Treated with Risperidone, Clozapine and Quetiapine

作　　者：卢世臣[1] 张淑爱[1] 任艳梅[1] 

机构地区：[1]济宁市精神病防治院精神四科,山东济宁272051

出　　处：《护理学杂志》2005年第3期57-59,共3页

摘　　要：目的比较利培酮、氯氮平、奎的平3种非典型抗精神病药对精神分裂症患者精神症状和生活质量的影响。方 法将96例精神分裂症患者随机分为3组,分别以利培酮(33例)、氯氮平(32例)、奎的平(31例)治疗并随访6个 月,评定其临床症状和生活质量。结果3种药物均能显著改善精神分裂症患者的临床症状和生活质量总评(P< 0.05或P<0.01),疗效相似(P>0.05);但利培酮能显著改善患者心理领域、独立性领域、社会关系领域和环境领 域生活质量(P<0.05或P<0.01);奎的平显著改善患者心理领域和社会关系领域(均P<0.01);氯氮平仅显著改 善心理领域(P<0.01)。结论在同样的治疗效果基础上,利培酮更有利于改善精神分裂症患者的生活质量。Objective To compare the psychopathology and the quality of life of schizophrenic patients who were treated with risperidone, clozapine and quetiapine respectively.Methods Ninety-six cases of schizophrenia according to CCMD-3 were divided three groups randomly and were treated with risperidone (n=33), clozapine (n=32) or quetiapine(n=31) respectively with a follow-up duration of 6 months. The clinical symptoms and quality of life were assessed with positive and negative symptoms scale (PANSS) and world health organization quality of life (WHO.QOL) respectively before and 1, 2, 3, 6 months after treatment.Resuls The degree of the improvement of the psychopathology was similar within the three groups. After treatment for 6 months, the 3 drugs all could improve the total assessment of patients’ life quality. Risperidone could significantly improve every aspect of patient's life quality except physical domain and spirit domain, while clozapine only improved the psychology domain, and quetiapine significantly improved psychology domain and environment domain.Conclusion Risperidone is more favorable for schizophrenia patients to return to society than clozapine and quetiapine. Quetiapine is also an ideal drug which is valuably popularized in clinical practice.

关 键 词：精神分裂症 生活质量 利培酮 氯氮平 奎的平 

分 类 号：R473.74[医药卫生—护理学] R749.3[医药卫生—临床医学]