异帕米星的临床评价60例  

Clinical appraisal of isepamicin in 60 patients

作　　者：朱峰[1] 王尔健[1] 张婴元[1] 吴卫红[1] 吴湜 吴培澄[1] 

机构地区：[1]上海医科大学附属华山医院抗生素研究所,上海200040

出　　处：《新药与临床》1993年第4期194-197,共4页

摘　　要：呼吸系和泌尿系感染60例(男性27例,女性33例;平均年龄52±15a),用异帕米星0.4-0.8g/d,分2次静滴或肌注,疗程9±3d。结果临床有效率为82％,细菌清除率75％。对19例血药浓度监测,峰浓度为17±7mg/L,谷浓度2±3mg/L。异帕米星和其他15种药物对53株临床分离菌的MIC测定提示该药对肠杆菌科、绿脓杆菌和葡萄球菌属等均具良好抗菌活性。Sixty patients (M 27, F 33; age 52 ± 15a) with lower respiratory tract infections and urinary tract infections received isepamicin 0.4-0.8g in 2 divided doses daily in- travenously or intramuscularly for 9 ± 3 d. The total response rate was 82% and bacteria clearance rate 75%. Therapeutic drug monitoring in 19 patients showed the mean peak concentration was 17 ± 7 mg/L and the trough concentration was 2 > 3 mg/L. The result of MIC of ise-pamicin and the other 15 antimicrobial agents against clinical isolates showed isepamicin had good activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococ-cus.

关 键 词：异帕米星 细菌感染 药敏实验 

分 类 号：R978.12[医药卫生—药品]