Synthesis of N-Phosphoryl Branched Peptides  

作　　者：ShengLiCAO HuaFU YuFenZHAO 

机构地区：[1]DepartmentofChemistry,Capital-NormalUniversity,Beijing100037 [3]TheKeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation DepartmentofChemistry,TsinghuaUniversity,Beijing100084

出　　处：《Chinese Chemical Letters》2005年第3期317-320,共4页中国化学快报（英文版）

基　　金：The authors would like to thank the financial supports from the National Natural Science Foundation of China(No.20132020);the Ministry of Science and Technology.the Chinese Ministry of Education and Tsinghua University.

摘　　要：H-phosphonates were conveniently prepared by direct transesterification of diphenyl phosphite (DPP) with the corresponding alcohols, without further purification they were reacted with branched peptide methyl ester (L-Leu2-L-LysOMe) through Atherton-Todd method, a series of different substituted alkyloxy (N-phosphoryl-L-Leu)2-L-LvsOMe were synthesized, and their structures were confirmed by P NMR, ESI-MS, H NMR,13 C NMR, IR and elemental analysis. 31 1 The approach possesses the advantages of easy operation, high yield and inexpensive phosphorylating reagent.

关 键 词：N-Phosphoryl branched peptide H-PHOSPHONATE Atherton-Todd reaction transesterification. 

分 类 号：O629.72[理学—有机化学]