尼卡地平在小儿体外循环期间控制血压的应用研究  

The clinical study on nicardipine in children's cardiac operation

作　　者：白洁[1] 陈煜[1] 张剑蔚[1] 

机构地区：[1]上海第二医科大学附属新华医院上海儿童医学中心,上海200127

出　　处：《儿科药学杂志》2005年第1期14-15,共2页Journal of Pediatric Pharmacy

摘　　要：目的:通过尼卡地平在小儿体外循环手术期间的应用,观察其控制血压的效果及血液浓度的变化.方法:40例小儿先天性心脏病、ASA Ⅱ级全麻患儿为观察对象,分为A、B两组,体外循环开始静脉维持应用尼卡地平2μg/(kg·min),并根据血压变化加以调节,测尼卡地平开始静脉输注不同时间段的血液浓度,术中监测血液动力学.结果:持续输注尼卡地平2～10μg/(kg·min),能在用药5 min后较满意地把血压控制在所需水平,起效快、作用确切、安全性大,作用消失后血压无反跳、心率影响不显著、副作用少.结论:尼卡地平降低动脉血压效果满意,是一种小儿体外循环手术期间控制血压的理想药物.Propose: The effects of blood pressure control and the change of nicardipine concentration of the blood were observed in children cardiac operation. Method: The 40 cases patient were divided in two groups. Nicardipine was used from the beginning of operation and on in the way of vein injection in 2 μg/(kg·min). The nicardipine concentrations of the blood were tested. The circulation dynamic was monitor. Result: The blood pressure during periods of operation was satisfactorily controlled. The drug takes an effect quickly. The side effect was not found. Conclusion: The nicardipine is an ideal drug for blood pressure control and very safe during the period of children cardiac operation.

关 键 词：尼卡地平 控制血压 体外循环手术 小儿 血液浓度 观察 血压变化 应用研究 降低 消失 

分 类 号：R544[医药卫生—心血管疾病] R654[医药卫生—内科学]