青光眼滤过术后辅助药物:甲壳类多糖的制备和初步研究(第1部分)药物制备和分子量降解初探  

Manufacture and preliminary study about polysaccharides in exoskeleton as an adjunctive drug afterglaucoma filtering surgery

作　　者：陆放[1] 黄亦武[1] 盛耀华[1] 王丽天[1] 陆道炎[1] 陈才根[1] 吴念祖[1] 周绍荣[1] 高正茂[1] 刘新泉 

机构地区：[1]上海第二医科大学附属新华医院眼科 [2]山东潍坊医学院附属益都中心医院眼科

出　　处：《眼外伤职业眼病杂志》1993年第3期169-171,共3页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

基　　金：上海市卫生局青年科研基金

摘　　要：我们从海洋生物虾、蟹的壳中提取了以甲壳质和甲壳胺为主要成份的甲壳类多糖,制成膜(高分子量)和溶液(低分子量)。其Pb含量为0.0045%。甲壳类多糖膜在37℃恒温的溶菌酶和乳酸钠林格氏溶液中18天内,分子量下降20961,置于兔眼青光眼滤过术后结膜下25天内,分子量下降45159。初步研究结果表明:甲壳类多糖膜分子量能自行降解。We Produce the solution and membrane ofpolysaccharides in exoskeleton(PSE) which areabstracted from the shell of shrimps and crabsof arthropods in ocean,which chiefly composedof Chitin and Chitosan. Plumbum content isabout 0.O045%. The molecular weights of itsmembrane are reduced by 20961 in balancesaline solution and lysoxyme at 37℃ after 18days,and reduced by 47159 in rabbit's eyes 25days after glaucoma filtering surgery. This pre-liminary results show that PSE can undergobiodegradation.

关 键 词：青光眼 眼外科手术 甲壳质 多糖 

分 类 号：R988.1[医药卫生—药品]