青光眼滤过术后辅助药物:甲壳类多糖的制备和初步研究——Ⅱ.抑制纤维细胞增殖作用初探  

Manufacture and preliminary study about polysaccharides in exoskeleton as an adjunctive drug after glancoma filtering surgery Ⅱ.preliminary study for inhibiting fibroblastic proliferation

作　　者：陆放[1] 黄亦武[1] 盛耀华[1] 王丽天[1] 陆道炎[1] 陈才根[1] 吴念祖[1] 周绍荣[1] 高正茂[1] 刘新泉 

机构地区：[1]上海第二医科大学附属新华医院眼科

出　　处：《眼外伤职业眼病杂志》1993年第4期254-255,共2页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：我们自行制备的甲壳类多糖膜和溶液能对体外培养成纤维细胞产生抑制作用,半数抑制量分别为:69.59mg/L和16.35mg/L,并与抗代谢药物噻替哌的抑制作用作了比较。甲壳类多糖的溶液在兔眼青光眼滤过术后能有效地抑制纤维细胞增生,维持滤过道通畅和降低眼压。The membrane and solution ofpolysaccharides in Exoskeleton abstracted byourselves can inhibit fibroblastic proliferationin cell culture, which ID_50 are 69.59mg/ Land 16.35mg/L, and they are compared withantimetabolitic drug: Thio-TEPA. Its solutioncan inhibit fibroblastic proliferation in rabbit'seyes after glaucoma filtering surgery, keep fil-tering channel unobstructed and reduceintraocular pressure.

关 键 词：青光眼 甲壳类 多糖 纤维细胞增生 

分 类 号：R988.1[医药卫生—药品]