牛珀至宝微丸影响内毒素休克大鼠急性肺损伤胶原纤维的表达  

The influence of Niu-po-zhi-bao pellet on collagen express in acute lung injury of endotoxin shock rat

作　　者：黎晖[1] 李春[1] 杜少辉[2] 李伊为[1] 陈东风[1] 周健洪[1] 邓汝东[1] 张赛霞[1] 

机构地区：[1]广州中医药大学基础医学院解剖学教研室,广州510405 [2]广东省深圳市中医院,518033

出　　处：《广东医学》2005年第2期156-158,共3页Guangdong Medical Journal

基　　金：国家自然科学基金项目 (编号 :3 9970 914 ) ;广东省中医药管理局项目 (编号 :2 0 40 0 0 5 );深圳市科技局项目 (编号 :2 0 0 0 0 40 87)

摘　　要：目的　观察牛珀至宝微丸对内毒素急性肺损伤时胶原纤维表达的影响。方法　静脉注射内毒素(LPS) 1 5mg/kg、腹腔注射D -氨基半乳糖 (D -Ga1N) 10 0mg/kg造成内毒素休克模型 ,用牛珀至宝微丸作干预处理 ,VanGieson法染色检测胶原纤维在肺组织内的表达。结果　内毒素造成严重的急性肺损伤 ,肺组织胶原纤维染色显著增强 ;牛珀至宝微丸能减轻肺损伤 ,肺组织胶原纤维染色明显减弱。结论　牛珀至宝微丸能减轻内毒素急性肺损伤和纤维化 ,可能有治疗急性肺损伤纤维化的作用。Objective To study the effect of Niu-po-zhi-pellet on collagen expression in acute lung injury of endotoxin shock rat. Methods Endotoxin shock model was induced by LPS and D-Ga1n. Pathological injury was examined by HE-stain and the expression of collagen was measured by Van Gieson's stain. Results Collagen staining was enhanced in acute lung injury, which with significantly reduced by Niu-po-zhi-bao pollet treatment. Conclusion Niu-po-zhi-bao pellet can improv acute lung injury of endotoxin shock by modulating collagen expression.

关 键 词：牛珀至宝微丸 肺纤维化 肺损伤 内毒素 胶原纤维 

分 类 号：R563[医药卫生—呼吸系统]