Synthesis and Crystal Structure of Spiro[1-bromo(S)-4-(R)-hydroxy-5-oxa-6-oxo-bicyclo[3.1.0]hexane-2,2'-(3'-diethyl-α-(S)-4''-Cl-benzyloxyphosphonyl-4'-(1R,2S,5R)-menthyloxybutyrolactone)]  被引量:2

Synthesis and Crystal Structure of Spiro[1-bromo(S)-4-(R)-hydroxy-5-oxa-6-oxo-bicyclo[3.1.0]hexane-2,2'-(3'-diethyl-α-(S)-4''-Cl-benzyloxyphosphonyl-4'-(1R,2S,5R)-menthyloxybutyrolactone)]

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作  者:范雪娥 傅玉琴 王建革 陈庆华 

机构地区:[1]Department of Chemistry,Luoyang Normal College,Luoyang 470022,China

出  处:《Chinese Journal of Structural Chemistry》2005年第2期163-168,共6页结构化学(英文)

基  金:Supported by the National Natural Science Foundation of China (No. 29672004)

摘  要:The title compound, spiro[1-bromo(S)-4-(R)-hydroxy-5-oxa-6-oxo-bicyclo[3.1.0]- hxane-2,2?-(3?-diethyl-α-(S)-4??-Cl-benzyloxyphosphonyl-4?-(1R,2S,5R)-menthyloxybutyrolact- one)] has been synthesized via the tandem asymmetric reaction and it crystallizes in a mono- clinic system, space group P21 with a = 11.067(3), b = 12.484(2), c = 12.356(2) ?, β = 101.95°, C29H39BrClO10P, Mr = 693.93, V = 1670.2(6) ?3, Z = 2, Dc= 1.380 g/cm3, λ(MoKα) = 0.071073 nm, μ = 1.410 mm-1, F(000) = 720, the final R = 0.0570 and wR = 0.0758 for 6190 observed reflections with I > 2σ(I). The structure is characterized by the special combination of biologic phosphonyl group and one cyclopropane as well as two butyrolactones. The intermolecular hydrogen bond between O(3)–H(3A)…O(10) in the crystal lattice has been observed.The title compound, spiro[1-bromo(S)-4-(R)-hydroxy-5-oxa-6-oxo-bicyclo[3.1.0]- hxane-2,2?-(3?-diethyl-α-(S)-4??-Cl-benzyloxyphosphonyl-4?-(1R,2S,5R)-menthyloxybutyrolact- one)] has been synthesized via the tandem asymmetric reaction and it crystallizes in a mono- clinic system, space group P21 with a = 11.067(3), b = 12.484(2), c = 12.356(2) ?, β = 101.95°, C29H39BrClO10P, Mr = 693.93, V = 1670.2(6) ?3, Z = 2, Dc= 1.380 g/cm3, λ(MoKα) = 0.071073 nm, μ = 1.410 mm-1, F(000) = 720, the final R = 0.0570 and wR = 0.0758 for 6190 observed reflections with I > 2σ(I). The structure is characterized by the special combination of biologic phosphonyl group and one cyclopropane as well as two butyrolactones. The intermolecular hydrogen bond between O(3)–H(3A)…O(10) in the crystal lattice has been observed.

关 键 词:functionalized phosphorus-cyclopropane compound multiple chiral centers crystal structure 

分 类 号:O627.51[理学—有机化学]

 

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