前胡香豆素A的分离和结构鉴定  

ISOLATION AND STRUCTURE ELUCIDATION OF QIANHUCOUMARIN A

作　　者：孔令义[1] 裴月湖[1] 李铣[1] 朱廷儒[1] 奥山徹 

机构地区：[1]沈阳药学院天然药物研究室 [2]日本明治药科大学生药教室

出　　处：《药学学报》1993年第6期432-436,共5页Acta Pharmaceutica Sinica

摘　　要：从中药白花前胡(Peucedanum praeruptorum Dunn)根中分离得到7个化合物,经理化常数和波谱数据的测定以及化学反应,鉴定为补骨脂素(Ⅱ)、5-甲氧基补骨脂素(Ⅲ)、8-甲氧基补骨脂素(Ⅳ)、北美芹素(Ⅴ)、peucedanocoumarin Ⅱ(Ⅵ)、β-谷甾醇(Ⅶ)和前胡香豆素A(Ⅷ)。Ⅷ为一新化合物,通过和凯林内酯的化学沟通确定了其绝对构型,化学结构为3′(R)-羟基-4′(E)-惕各酰氧基-3′,4′-二氢邪蒿内酯。Ⅱ～Ⅳ和Ⅶ为首次从白花前胡中分离得到。Seven compounds were isolated from the traditional Chinese Medicine Qianhu, roots of Peucedanum praeruptorum Dunn. Their structures were identified as psoralen (Ⅱ), 5-methoxyp soralen (Ⅲ), 8-methoxypsoralen (Ⅳ), pteryxin (Ⅴ), peucedanocoumarin Ⅱ (Ⅵ), β-sitosterol (Ⅶ) and qianhucoumarin A (Ⅷ) by physico-chemical constants and spectral analyses (UV, IR, ~1HNMR, ^(13)CNMR, ELMS). Ⅷ is a new compound with the structure of 3' (R)-hydroxy-4'(R)-tigloyloxy-3',4'-dihydroseslin. Its absolute configurations were determined by chemical correlation with known compounds. Ⅱ, Ⅲ, Ⅳ and Ⅶ were first isolated from this plant.

关 键 词：白花前胡 前胡香豆素A 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]