雷公藤叶中二萜化合物的研究  

STUDIES ON DITERPENOIDS FROM LEAVES OF TRIPTERYGIUM WILFORDII

作　　者：张崇璞[1] 吕燮余 马鹏程[1] 陈沄[1] 张永刚[1] 言政[1] 陈国芳[1] 郑启泰[2] 贺存恒[2] 于德泉[2] 

机构地区：[1]中国医学科学院皮肤病研究所,南京210042 [2]中国医学科学院药物研究所,北京100050

出　　处：《药学学报》1993年第2期110-115,共6页Acta Pharmaceutica Sinica

基　　金：国家"七五"攻关;国家自然科学基金;中国医学科学院科研基金

摘　　要：从雷公藤(Tripterygium wilfordii)叶中分离出九个二萜化合物,经物理常数测定、化学反应、以及波谱数据分析,分别鉴定为雷公藤内酯酮(triptonide,1)、雷公藤内酯醇(triptolide,2)、雷公藤内酯二醇(tripdiolide,3);雷醇内酯(triptolidenol,4)、16-羟基雷公藤内酯醇(16-hydroxytriptolide,5)、雷公藤氯内酯醇(tripehlorolide,6)、雷藤内酯三醇(triptriolide,7),以及新化合物雷公藤内酯二醇酮(tripdiotolnide,8)和13,14-环氧9,11,12-三羟雷公藤内酯(13,14-epoxide 9,11,12-trihydroxytriptolide,9)。新化合物的生物活性正在研究。Tripterygium wilfordii Hook f. has been used as a medicinal herb in traditional Chinese medicine and as an insecticide by the Chinese for hundreds of years. Recently, this plant has been used to treat cancer, rheumatic arthritis and various skin diseases in some Chinese clinics. It is of interest to note that Tripterygium also showed significant antifertility activities.The active principles of the anti-inflammatory, immunosuppressive and antifertile actions in Tripterygium are diterpenoid containing triepoxides, but information on its chemistry is limited to the woody part of the root and the rootbark. Recently, we have studies the leaves of Tripterygium (collected at Zhejiang province, China), and isolated two novel diterpenoids by chromatography named tripdioltonide (8) and 13, 14- epoxide 9, 11,12- trihydroxytriptolide ( 9 ), besides triptonide (1), triptolide (2), tripdiolide (3), triptolidenol (4), 16-hydroxyl-triptolide (5), tripchlorolide (6) and triptriolide (7). Their structures were established by chemical reactions, TLC, UV, MS, IR, ~1H-~1H COSY,~1H-^(13)C COSY, DEPT spectrometric investigation. The structure of tripdioltonide was further confirmed by X-ray analysis.

关 键 词：雷公藤 内酯二醇酮 

分 类 号：R284.1[医药卫生—中药学]