二十二碳六烯酸抗心血管病作用的研究——1、对家兔血小板聚集的影响  

THE STUDIES ON EFFECT OF DOCOSAHEXAENOIC ACID UPON CARDIOVASCULAR DISEASE I.THE IN VITRO INFLUENCE ON PLATELET AGGREGATION

作　　者：周序斌[1] 王景梓[1] 刘玉娥[2] 刘书慧[1] 吴葆杰[1] 

机构地区：[1]山东医科大学药理学教研室 [2]山东医科大学卫生学校

出　　处：《山东医科大学学报》1989年第3期5-7,共3页Acta Academiae Medicinae Shandong

基　　金：国家自然科学基金

摘　　要：家兔富血小板血浆与二十二碳六烯酸(DHA)10^(-4)M或二十碳五烯酸(EPA)10^(-4)M在37℃孵育2min,对胶原诱导聚集产生明显抑制作用,聚集抑制率分别为40.8±18.7%和42.8±20.4%。同浓度的DHA或EPA对ADP诱导聚集有抑制作用,但统计学差异不显著,对AA诱导血小板聚集无作用。实验结果表明,DHA对家兔血小板聚集功能的影响与EPA相似。The in vitro influence of dososahexaenoic acid(DHA)on rabbit platelet aggregation was invastigated with turbidity method in com- parison with eieosapentaenoic acid(EPA),After the PRP was incubuted with 10^(-4)M of DHA or EPA at 37℃ for 2 min,the aggregation induced by collagen was significantly inhibited.The rate of inhibited aggregation is 40.8±18.7% in DHA and 42.8±20.4% in EPA.ADP-induced platelet aggregation was decreased,but was not statistically significant.No inhibi- tion of aggregation-induced by AA(Arachidonic acid)could be observed both in DHA and in EPA.The result suggests that a significant inhibi- tion of the collagen-induced platelet aggregation similar to EPA was induced by DHA.

关 键 词：心血管药 脂纺酸类 血小板凝集 

分 类 号：R972[医药卫生—药品]