傣药小灯台中的吲哚生物碱  

STUDIES ON THE INDOLE ALKALOIDS OF WINCHIA CALOPHYLLA A. DC.

作　　者：李朝明[1] 张宪民[1] 周韵丽[2] 黄丽瑛[2] 陶国达[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学开放实验室,昆明650204 [2]中国科学院上海药物研究所,上海200031

出　　处：《药学学报》1993年第7期512-515,共4页Acta Pharmaceutica Sinica

摘　　要：从傣药小灯台(Winchia catophylla A. DC.)中分到4个吲哚生物碱,经理化常数测定,光谱分析和化学转化,分别鉴定为echitamine chloride(Ⅰ),echitamidine(Ⅱ),N_b-demethyl-echitamine(Ⅲ)和22-O-acetyl-N_--demethyl-echitamine(Ⅳ),其中Ⅳ为新的吲哚生物碱。Winchia calophylla A. DC. (Apocynaceac) is one traditional medicine of the Dai Nationality in Xishuangbanna, Yunnan Province, for the treatment of trachitis. Four indole alkaloids have been isolated from the stem bark and the leaves of this plant by aluminum oxide and silica gel chromatography. Three of them were identified as echitamine chloide (Ⅰ), echitamidine (Ⅱ) and N_b-demethyl-echitamine (Ⅲ) by comparison with literature. One of them are new, with strutures elucidated as 22-O-acetyl-N_b-demethyl-echitamine (Ⅳ) by chemical and spectroscopic methods.

关 键 词：夹竹桃科 小灯台 吲哚生物碱 

分 类 号：R931.6[医药卫生—生药学]