氯丙嗪与维拉帕米合用对大鼠心肌缺血再灌注损伤的保护作用  

PROTECTIVE EFFECTS OF COMBINATION OF CHLORPROMAZINE AND VERAPAMIL ON ISCHEMIA-REPERFUSION INDUCED INJURY IN RAT MYOCARDIUM

作　　者：邓颖[1] 张志善[1] 

机构地区：[1]湖北医学院药理教研室,武汉430071

出　　处：《药学学报》1993年第8期561-566,共6页Acta Pharmaceutica Sinica

摘　　要：氯丙嗪与维拉帕米合用,可明显降低大鼠心肌缺血再灌注诱发心律失常和室颤发生率;降低再灌注后血清CPK及心肌匀浆尤其是线粒体中的MDA含量的升高;增加线粒体中的磷脂含量,提高磷脂/胆固醇比值;并可明显降低再灌注区心肌“细胞内钙”含量。结果表明,两药合用较单用氯丙嗪或维拉帕米为优。Combination of chlorpromazine (CPZ) and verapamil (Ver) was found to decrease the incidence of ventricular arrhythmias and ventricular fibrillation induced by myocardial ischemia and reperfusion, lower serum creatine phosphokinase (CPK) and decrease the content of malondialdehyde (MDA) in heart tissue homogenate especially in mitochondria; and increase the phospholipid content and the phospholipid/cholesterol ratio; and decrease the myocardial 'cell calcium' content in the reperfused area. The effect of CPZ and Ver combination was better than either CPZ and Ver alone.

关 键 词：氯丙嗪 维拉帕米 再灌注损伤 

分 类 号：R965.1[医药卫生—药理学]